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Exhaled breath condensate cysteinyl leukotrienes are increased in children with exercise-induced bronchoconstriction  Silvia Carraro, MD, Massimo Corradi,

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Presentation on theme: "Exhaled breath condensate cysteinyl leukotrienes are increased in children with exercise-induced bronchoconstriction  Silvia Carraro, MD, Massimo Corradi,"— Presentation transcript:

1 Exhaled breath condensate cysteinyl leukotrienes are increased in children with exercise-induced bronchoconstriction  Silvia Carraro, MD, Massimo Corradi, MD, FCCP, Stefania Zanconato, MD, PhD, Rossella Alinovi, BSc, Maria Francesca Pasquale, MD, Franco Zacchello, MD, Eugenio Baraldi, MD  Journal of Allergy and Clinical Immunology  Volume 115, Issue 4, Pages (April 2005) DOI: /j.jaci Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

2 Fig 1 Cys-LT levels in EBC of asthmatic children with EIB, asthmatic children without EIB, and healthy control children. Open circles represent samples in which the Cys-LT concentration was less than the detection limit. Horizontal bars represent median values. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

3 Fig 2 Ammonia levels in EBC of asthmatic children with EIB, asthmatic children without EIB, and healthy control children. Horizontal bars represent median values. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

4 Fig 3 Maximal FEV1 decrease after exercise in asthmatic children with EIB at baseline and after 3 days of treatment with montelukast. Horizontal bars represent mean values. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

5 Fig 4 Correlation between EBC Cys-LT baseline concentrations and maximal postexercise FEV1 decrease in asthmatic children (P < .01; r=0.7). Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

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