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CTNNA3 and SEMA3D: Promising loci for asthma exacerbation identified through multiple genome-wide association studies  Michael J. McGeachie, PhD, Ann.

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Presentation on theme: "CTNNA3 and SEMA3D: Promising loci for asthma exacerbation identified through multiple genome-wide association studies  Michael J. McGeachie, PhD, Ann."— Presentation transcript:

1 CTNNA3 and SEMA3D: Promising loci for asthma exacerbation identified through multiple genome-wide association studies  Michael J. McGeachie, PhD, Ann C. Wu, MD, Sze Man Tse, MD, George L. Clemmer, MS, Joanne Sordillo, ScD, Blanca E. Himes, PhD, Jessica Lasky-Su, PhD, Robert P. Chase, MS, Fernando D. Martinez, MD, Peter Weeke, MD, Christian M. Shaffer, BS, Hua Xu, PhD, Josh C. Denny, MD, Dan M. Roden, MD, Reynold A. Panettieri, MD, Benjamin A. Raby, MD, Scott T. Weiss, MD, Kelan G. Tantisira, MD  Journal of Allergy and Clinical Immunology  Volume 136, Issue 6, Pages (December 2015) DOI: /j.jaci Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 CAMP permutation versus joint CAMP–CARE Network P values from meta-analysis for the top GWAS SNPs. Stars indicate SNPs and are annotated with gene symbols in cases in which the SNP is within a gene. The diagonal line indicates x = y; SNPs that did not change P values from CAMP permutation testing to CAMP–CARE Network meta-analysis are close to this line. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 CTNNA3 eQTL plot for rs The suspected regulatory SNP rs is labeled and highlighted with a purple diamond. rs is indicated with a black arrow. Other SNPs are colored with their LD to rs (r2), indicating a locus of SNPs nearby that might have action on CTNNA3 expression. The illustration was generated with LocusZoom. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig E1 Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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13 Fig E10 Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions


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