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Genomic and proteomic determinants of lower extremity revascularization failure: Rationale and study design  Peter R. Nelson, MD, Kerri A. O’Malley, PhD,

Published byVebjørn Møller Modified over 5 years ago

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Presentation on theme: "Genomic and proteomic determinants of lower extremity revascularization failure: Rationale and study design  Peter R. Nelson, MD, Kerri A. O’Malley, PhD,"— Presentation transcript:

1 Genomic and proteomic determinants of lower extremity revascularization failure: Rationale and study design  Peter R. Nelson, MD, Kerri A. O’Malley, PhD, Robert J. Feezor, MD, Lyle L. Moldawer, PhD, James M. Seeger, MD  Journal of Vascular Surgery  Volume 45, Issue 6, Pages A82-A91 (June 2007) DOI: /j.jvs Copyright © 2007 The Society for Vascular Surgery Terms and Conditions

2 Fig 1 Study overview. LE PAOD, lower extremity peripheral arterial occlusive disease; CLI, critical limb ischemia; ABI, ankle-brachial index; SF-36, Short Form 36. Journal of Vascular Surgery  , A82-A91DOI: ( /j.jvs ) Copyright © 2007 The Society for Vascular Surgery Terms and Conditions

3 Fig 2 Study timeline. ABI, Ankle-brachial index; SF-36, Short Form 36.
Journal of Vascular Surgery  , A82-A91DOI: ( /j.jvs ) Copyright © 2007 The Society for Vascular Surgery Terms and Conditions

4 Fig 3 Timing of phlebotomy for genomic and proteomic analysis. See Fig 2 for correlation with clinical outcome assessment. WBC, White blood cells; MO RNA, monocyte ribonucleic acid. Journal of Vascular Surgery  , A82-A91DOI: ( /j.jvs ) Copyright © 2007 The Society for Vascular Surgery Terms and Conditions

5 Fig 4 A, Representative heat map display of microarray data using time series (B) and supervised analytic approaches. MODS, multiorgan dysfunction syndrome. (Used by permission, Feezor RJ, Baker HV, Xiao W, et al. Genomic and proteomic determinants of outcome in patients undergoing thoracoabdominal aortic aneurysm repair. J Immunol 2004;172: )62 Journal of Vascular Surgery  , A82-A91DOI: ( /j.jvs ) Copyright © 2007 The Society for Vascular Surgery Terms and Conditions

6 Fig 5 Representative proteomic heat map. MODS, Multiorgan dysfunction syndrome; IL, interleukin; MCP-1, monocyte chemotactic protein-1; IP-10, interferon-γ inducible protein-10; MIG, monokine induced by IFNγ; sICAM, soluble intercellular adhesion molecule-1; TRAIL, tumor necrosis factor-related apoptosis-inducing ligand treatment; IFNg, interferon-γ; TGFb, transforming growth factor-β; GM-CSF, granulocyte-macrophage colony-stimulating factor; GCSF, granulocyte colony-stimulating factor; TNFα, tumor necrosis factor-α; MCP-3, monocyte chemotactic protein-3; TNFβ, tumor necrosis factor-β. (Used by permission, Feezor RJ, Baker HV, Xiao W, et al. Genomic and proteomic determinants of outcome in patients undergoing thoracoabdominal aortic aneurysm repair. J Immunol 2004;172: )62 Journal of Vascular Surgery  , A82-A91DOI: ( /j.jvs ) Copyright © 2007 The Society for Vascular Surgery Terms and Conditions

7 Fig 6 Representative display of inflammatory pathway analysis (Ingenuity Pathway Analysis, Ingenuity Systems, Journal of Vascular Surgery  , A82-A91DOI: ( /j.jvs ) Copyright © 2007 The Society for Vascular Surgery Terms and Conditions

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