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Figure 3 Stepwise strategy of bioinformatic analysis of sequencing results We obtained 7,292,715 and 303,698 DNA sequence reads from the affected brain.

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Presentation on theme: "Figure 3 Stepwise strategy of bioinformatic analysis of sequencing results We obtained 7,292,715 and 303,698 DNA sequence reads from the affected brain."— Presentation transcript:

1 Figure 3 Stepwise strategy of bioinformatic analysis of sequencing results We obtained 7,292,715 and 303,698 DNA sequence reads from the affected brain tissues of patients 3 and 4, respectively. Stepwise strategy of bioinformatic analysis of sequencing results We obtained 7,292,715 and 303,698 DNA sequence reads from the affected brain tissues of patients 3 and 4, respectively. After trimming off low-quality sequence regions, we mapped them to the human genome and messenger RNA (mRNA) reference sequences using CLC Genomics Workbench. The 272,518 reads from patient 3 (3.7% of the total reads) and the 56,534 reads from patient 4 (18.6% of the total reads) that aligned with neither the human genome nor the mRNA reference sequences were further analyzed using BLASTN against the nucleotide database with a cutoff E-value of <1e∼20. LMD = laser microdissection; NCBI = National Center for Biotechnology Information; PAS = periodic acid-Schiff. Yusuke Sakiyama et al. Neurol Neuroimmunol Neuroinflamm 2015;2:e143 © 2015 American Academy of Neurology

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