1. Is collagen fiber damage the cause of early softening in articular cartilage? 
S.M. Hosseini, M.B. Veldink, K. Ito, C.C. van Donkelaar 
Osteoarthritis and Cartilage 
Volume 21, Issue 1, Pages (January 2013)
DOI: /j.joca
Copyright © 2012 Osteoarthritis Research Society International Terms and Conditions

2. Fig. 1
(a): Indenter displacement against time to monitor softening (control group, blue line) and to apply peak loads (increasing load group, red line) (Cartilage thickness 1 mm). (b): Typical relaxation curve during 10% indentation: peak value (black dot), equilibrium value (green line), and force reduction value (red arrow).
Osteoarthritis and Cartilage  , DOI: ( /j.joca )
Copyright © 2012 Osteoarthritis Research Society International Terms and Conditions

3. Fig. 2
Normalized peak values (mean + 95% confidence intervals). Reported P-values are those comparing the values of the 11 cycles within each loading protocol. n is the number of independent samples, and m is the number of femurs used to collect samples.
Osteoarthritis and Cartilage  , DOI: ( /j.joca )
Copyright © 2012 Osteoarthritis Research Society International Terms and Conditions

4. Fig. 3
Normalized equilibrium values (mean + 95% confidence intervals). Reported P-values are those comparing the values of the 11 cycles within each loading protocol. n is the number of independent samples, and m is the number of femurs used to collect samples.
Osteoarthritis and Cartilage  , DOI: ( /j.joca )
Copyright © 2012 Osteoarthritis Research Society International Terms and Conditions

5. Fig. 4
Bar graph with all FRP per experiment type displayed as subtraction of (a): the second from the first cycle value, b: the last from the first cycle value. (Mean ± 95% confidence intervals).
Osteoarthritis and Cartilage  , DOI: ( /j.joca )
Copyright © 2012 Osteoarthritis Research Society International Terms and Conditions

6. Fig. 5
Average compositional parameters per experiment type. GAG and collagen fractions are normalized to the dried weight of the sample. (Mean ± 95% confidence intervals).
Osteoarthritis and Cartilage  , DOI: ( /j.joca )
Copyright © 2012 Osteoarthritis Research Society International Terms and Conditions

7. Fig. 6
Typical histological sections from two samples per staining: (a, b): picrosirius red, (c, d): safranin O/fast green, (e, f): Col2-3/4M, (g, h): Col2-3/4Cshort, (i): Col2-3/4M positive control. Left: from 6 N experiments, right: from 15 N experiments.
Osteoarthritis and Cartilage  , DOI: ( /j.joca )
Copyright © 2012 Osteoarthritis Research Society International Terms and Conditions