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Anne Burdess, MBChB, Alastair F

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1 Perioperative platelet and monocyte activation in patients with critical limb ischemia 
Anne Burdess, MBChB, Alastair F. Nimmo, MBChB, Neil Campbell, BMedSci, Scott A. Harding, MBChB, MD, O.J. Garden, MBChB, MD, A. Raymond Dawson, MBChB, MD, David E. Newby, MBChB, PhD  Journal of Vascular Surgery  Volume 52, Issue 3, Pages (September 2010) DOI: /j.jvs Copyright © 2010 Society for Vascular Surgery Terms and Conditions

2 Fig 1 Scatter dot plots are shown for resting in vivo platelet activation in healthy volunteers (HV, ■), claudicants (Δ), patients with critical limb ischemia (CLI, ▾), patients with non-ST elevation myocardial infarction (NSTEMI, ♦), and patients undergoing arthroplasty (•). A, Percentage of platelet-monocyte aggregation. B, Percentage of platelet P-selectin expression. C, Platelet-derived microparticles (/mL). The horizontal lines represent population means (n = 30 per group). Analysis by one-way analysis of variance with Bonferroni post-tests. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2010 Society for Vascular Surgery Terms and Conditions

3 Fig 2 Resting in vivo monocyte activation in healthy volunteers (HV, ■), claudicants (Δ), patients with critical limb ischemia (CLI, ▾), patients with non-ST elevation myocardial infarction (NSTEMI, ♦), and patients undergoing arthroplasty (•). A, Percentage of monocyte CD40 expression. B, Monocyte CD11b (mean fluorescent intensity, MFI). Horizontal lines represent population means (n = 30 per group). Analysis by one-way analysis of variance with Bonferroni post-tests. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2010 Society for Vascular Surgery Terms and Conditions

4 Fig 3 Perioperative in vivo platelet activation is shown in patients undergoing surgery for critical limb ischemia (▾) and arthroplasty (•). Platelet activation in patients undergoing infrainguinal bypass or amputation was greater than in patients undergoing arthroplasty throughout the perioperative period (P < .0001). In vivo platelet activation measured by (A) percentage of platelet-monocyte aggregation (P < .05) and (B) percentage of P-selectin expression (P < .05), rose immediately postoperatively in patients undergoing arthroplasty but fell in those with critical limb ischemia (P < .001). Mean ± standard deviation; analysis between patient groups by two-way analysis of variance with repeated measures; analysis between time points for the same patient group by one-way analysis of variance with Bonferroni post-tests. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2010 Society for Vascular Surgery Terms and Conditions

5 Fig 4 Perioperative monocyte activation in patients undergoing surgery for critical limb ischemia (▾) and arthroplasty (•). Monocyte activation in patients undergoing infrainguinal bypass or amputation was significantly greater than in patients undergoing arthroplasty throughout the whole perioperative period (P < .0001). A, Percentage monocyte CD40 expression tended to rise immediately postoperatively in orthopedic patients before returning to baseline (P < .05) B, There was no significant postoperative change in monocyte CD11b (mean fluorescent intensity) in arthroplasty patients (P > .05), but levels appeared to rise on day 1 after surgery in those with critical limb ischemia (P < .05). Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2010 Society for Vascular Surgery Terms and Conditions

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