1. WT‐HSCT, LV. IDS, and LV. IDS
WT‐HSCT, LV.IDS, and LV.IDS.ApoEII normalize skeletal defects, peripheral inflammation, and heart failure markers in MPS II mice
WT‐HSCT, LV.IDS, and LV.IDS.ApoEII normalize skeletal defects, peripheral inflammation, and heart failure markers in MPS II mice ARepresentative X‐ray images of control and treated MPS II mouse craniums at 8 months of age. White arrows indicate the area where zygomatic arches are measured.B–DZygomatic arch widths (B), humerus widths (C), and femur widths (D) were analyzed using ImageJ software, n = 5–11.ERepresentation of the accelerating rotarod.FEight‐month‐old control and treated mice were trialed three times on the accelerating rotarod for a maximum of 300 s (4–4 rpm over 300 s), n = 12–16 mice/group.G–ICytokine bead arrays measuring MCP‐1 (G), MIP‐1α (H), and RANTES (I) were performed on liver lysates of 8‐month‐old mice using flow cytometry, n = 4–6.J, KGene expression of Nppb (J) and Myh7 (K) in hearts of control and treated MPS II animals (WT n = 3; MPS II n = 4; WT‐HSCT, LV.IDS, and LV.IDS.ApoEII n = 6).LIDS‐specific IgG antibody titers were measured in plasma (pos. control n = 1, neg. control (uninjected MPS II plasma) n = 6, LV.IDS/LV.IDS.ApoEII n = 6).Data information: Data are mean ± SEM, one‐way ANOVA, *P < 0.05, **P < 0.01, ***P < 0.001, ****P <  vs. MPS II.
Hélène FE Gleitz et al. EMBO Mol Med. 2018;emmm
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