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The Other Face of Chimeric Antigen Receptors

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Presentation on theme: "The Other Face of Chimeric Antigen Receptors"— Presentation transcript:

1 The Other Face of Chimeric Antigen Receptors
Gianpietro Dotti  Molecular Therapy  Volume 22, Issue 5, Pages (May 2014) DOI: /mt Copyright © 2014 The American Society of Gene & Cell Therapy Terms and Conditions

2 Figure 1 CAR function in (a) effector T cells to eliminate tumor cells and (b) nTregs to control autoimmune diseases. Costimulation in CAR-redirected nTregs remains to be defined. CAR, chimeric antigen receptor; MHC, major histocompatibility complex; nTregs, native T-regulatory cells; scFv, single-chain variable fragment; TCR, T-cell receptor. Molecular Therapy  , DOI: ( /mt ) Copyright © 2014 The American Society of Gene & Cell Therapy Terms and Conditions


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