1. Advanced Parkinson Disease: Are We Breaking New Ground?

3. Program Overview

4. Progression of PD

5. Motor and Non-Motor Symptoms in PD

6. Non-Motor Features of PD Affect the Whole Body

7. Non-Motor Symptoms in PD: Advanced Stages

8. Most Troublesome Symptoms in Advanced PD: The Patient's Perspective

9. Non-Motor Symptoms: Correlation of QoL Measures

10. Progression to Advanced PD

11. Increased Motor Severity And Increased Costs Related to Loss of Independence

12. Increase in Wearing-Off Motor Symptoms With Disease Duration: Negative Impact on QoL

13. Evolution From Early to Advanced PD Based on Changes in Levodopa Response

14. Pharmacokinetics of Levodopa and Delayed Gastric Emptying in PD

15. Adjunct Therapies to Levodopa: Evidence-Based Review

16. Device-Aided Therapies in PD

17. Multicenter Comparative Observational Study of Apomorphine and Levodopa Infusion in PD: EuroInf

18. GLORIA Registry: Levodopa-Carbidopa Intestinal Gel in Advanced PD

19. Effects of Bilateral Subthalamic Stimulation on Non-Motor Symptoms in PD

20. Summary of Device-Aided Approaches

21. Patient Profiles for Good Candidates for Device-Aided Treatments: Consensus Panel

22. Impulse Control Disorders and Infusion Treatment: EuroInf

23. Patient Behavior on Device-Aided Therapies Can Be Difficult to Predict

24. Role of Infusion Therapies for Advanced Age and Palliative Care

25. Clinician Perspective on Infusion Use in Nursing Home Setting: Patients With Cognitive Decline

26. Device-Aided Therapy: Role of the Caregiver

27. Caregiver Burden With Infusion Therapy

28. Recommendations for Informing Patients and Caregivers About Device-Aided Therapy: Consensus Report

29. Concluding Remarks (I)

30. Concluding Remarks (II)

31. Abbreviations

32. Abbreviations (cont)