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A Case of Cocaine-Induced Acute Interstitial Nephritis

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1 A Case of Cocaine-Induced Acute Interstitial Nephritis
David Wojciechowski, DO,, Bhaskar Kallakury, MD,, Pouneh Nouri, MD  American Journal of Kidney Diseases  Volume 52, Issue 4, Pages (October 2008) DOI: /j.ajkd Copyright © 2008 National Kidney Foundation, Inc. Terms and Conditions

2 Figure 1 (A) Hematoxylin and eosin–stained section shows interstitial inflammatory cell infiltrate in the cortex associated with edema and tubular injury. The 2 glomeruli show minor abnormalities. (B) Interlobular artery shows prominence and bulging of the endothelium into the lumen, but no vasculitis. (C, D, E) Interstitial edema and diffuse interstitial inflammatory cell infiltration with eosinophils (C, inset), tubules show degeneration with sloughed cells (D, E) and leukocytes (D) in the lumen. (F) Reactive tubule with cellular debris and some detached epithelial cells (arrows) in the lumen. Arrowhead points to an eosinophil with its characteristic vivid eosinophilic granular cytoplasm (original magnification: [A] ×100, [B to E] ×200, [F, inset in C] ×400). American Journal of Kidney Diseases  , DOI: ( /j.ajkd ) Copyright © 2008 National Kidney Foundation, Inc. Terms and Conditions


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