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Volume 95, Issue 5, Pages (August 2017)

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1 Volume 95, Issue 5, Pages 983-985 (August 2017)
Ligand-Selective Wnt Receptor Complexes in CNS Blood Vessels: RECK and GPR124 Plugged In  Harald J. Junge  Neuron  Volume 95, Issue 5, Pages (August 2017) DOI: /j.neuron Copyright © 2017 Elsevier Inc. Terms and Conditions

2 Figure 1 Receptor Complexes in CNS Angiogenesis and Blood-CNS Barrier Formation Left: GPR124 and RECK are ligand-specific co-activators for WNT7/β-catenin signaling. Cho et al. (2017) show in this issue of Neuron that RECK and GPR124 cooperate in CNS endothelial cells and associate with Wnt receptor complexes in a WNT7A/B-specific manner. Right: a related receptor complex in retinal endothelial cells mediates Norrin signaling via Frizzled4. The tetraspanin TSPAN12 is a ligand-specific amplifier of signaling. Next to its function in the retina, Norrin regulates the cerebellar blood-brain barrier. Norrin and Wnt7A/B operate in parallel pathways in some brain regions, e.g., the embryonic hindbrain. Modified from Lai et al. (2017). Neuron  , DOI: ( /j.neuron ) Copyright © 2017 Elsevier Inc. Terms and Conditions

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