1. Reversible Restrictive Cardiomyopathy Due to Light-Chain Deposition Disease 
Motoyuki Nakamura, MD, Mamoru Satoh, MD, Shugo Kowada, MD, Hidetoshi Satoh, MD, Atsushi Tashiro, MD, Fumitoshi Sato, MD, Tomoyuki Masuda, MD, Katsuhiko Hiramori, MD 
Mayo Clinic Proceedings 
Volume 77, Issue 2, Pages (February 2002)
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2. Figure 1
Standard 12-lead electrocardiogram before (A, September 1998) and 3 years after (B, July 2001) therapy. ST-T changes in I, aVL, and V3 through V6 observed in October 1998 (A) were completely eliminated after remission of multiple myeloma in July 2001 (B).
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3. Figure 2
Left ventricular geometric and functional changes before (A, September 1998) and 3 years after (B, July 2001) therapy. Long-axis view of 2-dimensional echocardiography (top), M-mode echocardiography (middle), and spectral tracing of pulsed Doppler left ventricular inflow velocity (bottom). Left ventricular wall thickness was normalized (septum, from 17 to 9 mm; posterior wall, from 18 to 10 mm) with disappearance of granular sparkling texture (top and middle) and improvement in diastolic function (early-to-atrial peak transmitral velocity ratio from 3.38 to 0.96; deceleration time, from 105 to 235 milliseconds) (bottom).
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4. Figure 3
Histological section of right endomyocardial biopsy specimen (original magnification x250). Light microscopy showed deposition of eosinophilic fibrillar substances in the interstitium (top). These substances were negative for Congo red staining and showed no apple green birefringence on polarized microscopy. Immunohistochemical studies revealed positive staining of the substances for κ light chain around the myocardial cells and the interstitium (arrows) (bottom).
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5. Figure 4
Electron microscopy showed electron dense deposits with a granular and fibrillar appearance in the interstitium (original magnification x20,000).
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6. Figure 5
Serial changes in an echocardiographic diastolic functional marker (E/A), with left ventricular posterior wall (PW) thickness and interventricular septum (IVS) thickness.
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