1. Astrocyte and microglial markers associated with neuroinflammation are increased across the ALS‐FTD spectrum
Astrocyte and microglial markers associated with neuroinflammation are increased across the ALS‐FTD spectrum I‐graph of M6 module (red) representing hub proteins and corresponding gene symbols as nodes. Node size and edges (gray) are reflective of the degree of intramodular connectivity (kME). Specific cell‐type expression is demonstrated by the node rim and text color around the gene symbols (blue: microglial marker and green: astrocytic marker).Relative abundance measured by label‐free quantification (log2 expression values) for the astrocytic hub proteins HEPACAM and GFAP, and the microglial hub proteins MSN and TPP1 were increased in ALS/FTD and FTD cases consistent with the positive correlation of M6 to pathological TDP‐43 pathological burden and clinical dementia. Box plots depict mean (horizontal bars) and variance (25th to 75th percentiles), with whiskers extending to the last non‐outlier measurements, as shown.
Mfon E Umoh et al. EMBO Mol Med. 2017;emmm
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