1. ColoPlus – benefits by value adding

2. About ColoPlus AB a private Swedish biotechnology company
develops clinically proven products in Bioactive Nutrition
the ColoPlus team:
renowned medical scientists
biotechnology professionals
business leaders
we offer:
exclusive license and knowhow worldwide

3. Bovine colostrum – sleeping local resource
Significant potential when processed under scientific control and administered for optimal effect as food product.
Profitable additional business for biotech innovators.
Value adding innovation – to be offered as single food product ColoPlus or integrated in existing porridge or cereals..

4. ColoPlus® IMCARE bovine colostrum porridge mix
based on natural nutrition
rich in bioactive properties
boosts immune defence
supports nutritional status
clinically proven
- therapeutic effect
- nutritional effect
granted international patents
exploring colostrum
- local sleeping resource

5. ColoPlus + Africa a love story

6. Clinical study – Gulu, Uganda

7. Clinical results Clinical studies Uganda (2) and Nigeria (1)
stopping diarrheas
increasing CD4+ cell counts – marker of immunity recovery
achieving weight gain, increasing hemoglobin and serum albumin – markers of nutritional status
reducing fatigue levels, improving a sense of well-being and functionality in immune-suppressed adults and children
These findings are in published studies:
World Journal of AIDS, 2015, 5, ;
Indian Journal of Gastroenterology, 2011, 30(6): ;
Scandinavian Journal of Gastroenterology 2006, 41, ;

8. ColoPlus® IMCARE concept: Bioactive agents and nutrition in combination
Mechanism of action
Immunoglobulins give local effect preventing intestinal infections. They attack food- and water-borne organisms that cause disease.
Other bioactivities (growth factors, lactoperoxidase, proline-rich peptides, minerals, vitamins) act systemic.
Macronutrients (i.e. essential amino acids, high value proteins, carbohydrates) enhance nutritional status.
Effect starts already in the mouth and continues along GI mucous membrane

9. ColoPlus as porridge – superior administration form
A dry porridge powder composed of two parts:
a bioactive part – bovine colostrum
a vehicle - formed by organic particulate matter
Good way to administer an effective dose of colostrum
Safe way to administer bioactivities: Protective effect of a matrix.
Influence on emptying of stomach (Particle size, viscosity - increase in gastric residence time, decrease of dissolution rate of the bioactivities);

10. ColoPlus® IMCARE nutritional facts/bioactive components
Nutrional facts
per 100 g
Energy (kJ/kcal)
1650/350
Proteins (g) 23
Fat (g) 2
Carbohydrates (g) 69
Lactose (g) 6
Dietary fibers (g)
1.8
Major bioactive components
per 100 g
IgG (g)
7.4
IgA (g)
1.1
Proline-rich polypeptides (g)
1.5
Lactoferrin (g)
0.5
Lactoperoxidase (g)
0.2
TGF-β (mg)
8.3
IGF-1 (µg)
100
IGF-2 (µg)
7.2
TGF-α (µg)
0.8

11. License: Gowardhan Dairy group, India
Parag Milk Foods Ltd

13. Colostrum collection for ColoPlus use
Requirements to contracted farms:
not using BST in breeding or milk production practice
antibiotic free
Quality of liquid colostrum is ensured by
collection during time frame according to quality specifications
testing on regular basis for the presence of antibiotics, pesticides, heavy metals and disease-causing pathogens
Critical points for quality
Colostrum
collection
Three qualities
24 h, 48 h, 72 h
Freezing
-18 °C
Time !!
Time of
storage
before
processing
Colostrum 24 hrs
Colostrum 48 hrs
Colostrum 72 hrs
Microbiological quality
Liquid
colostrum

14. Colostrum processing in production unit
Filtration
Heat
treatment
Drying
Colostrum
powder
Processing
Fat
separation
Liquid or frozen
colostrum
from farm
Common dairy equipment including spray-/freeze dryer
Colostrum powder should be prepared
under controlled conditions
from colostrum of good quality according to specifications
Colostrum milk should be tested for the presence of antibiotics, pesticides, heavy metals and disease-causing pathogens and for the level of biological activity

15. Acknowledgements IKEA Foundation; Swedish Embassy, Kampala, Uganda;
Ministry of Health, Uganda;
Gulu Women Economic Development and Globalisation, Uganda;
The Districts of Amuru, Gulu and Nwoya-Northern Uganda;
Research Teams;
The participants (Community).