1. Introduction to medical immunology
This powerpoint file is new
…to be added to “Serotonin” files
Introduction to medical immunology
Ali Al Khader, MD
Faculty of Medicine
Al-Balqa’ Applied University

3. Lines of defense *We have 2 lines of defense:
-First line: Innate immune system (including mechanical barriers)
-Second line: Adaptive immune system
*In some textbooks:
3 lines of defense…considering mechanical barriers alone as the first line of defense followed by innate immune system then adaptive immune system

4. Innate immune system = “natural” = “native”
-Germline: prepared before exposure
…the defense is direct or just needs some activation after exposure
-Mainly against microbes
-With repetition…the response is the same
-Identify groups of related microbes…not distinguishing fine differences
…limited diversity

5. Adaptive immune system = “acquired” = “specific”
It adapts: performance with repetitive exposure…the ability to remember
High specificity… distinguishing fine differences…the specific target molecules = antigens
Large diversity… by somatic recombination of gene segments
Immunoglobulins…by B lymphocytes
..will be explained later

7. 1ry VS 2ry lymphoid organs
…they are the organs or tissue in which lymphocytes are produced
…they are:
-Bone marrow (postnatally) & yolk sac/fetal liver/fetal spleen (in embryo)
…where both B & T lymphocytes are produced
-Thymus…where T lymphocytes development is completed
*Note: by puberty, most lymphopoiesis is of B type (in the marrow of flat bones)
2ry lymphoid organs:
…they are the organs or tissue where:
…they are: lymph nodes, spleen, mucosa-associated lymphoid tissues (MALT) & skin
Lymphocytes come into contact with foreign antigen, are clonally expanded & mature into effector cells

8. Our syllabus (by powerpoint files)
Our syllabus and a brief general introduction
Components of innate immune system
Reactions of innate immunity
Antigens
Major histocompatibility complex (MHC)
Immunoglobulins 1 + tests to detect antigens and antibodies
Immunoglobulins 2
Complement system
Development of T and B lymphocytes
T cell-mediated immunity
Effector mechanisms of humoral immunity
Mucosal immunity
Clinical cases
Immunological tolerance
Autoimmune diseases
Hypersensitivity
Immunodeficiency 1
Immunodeficiency 2
Vaccinations 1
Vaccinations 2
Transplantation immunology
Tumor immunology
Immunohematology

9. Our schedule until 29/10/2018 23/9 Sun 25/9 Tue 30/9 Sun 2/10 Tue
10/10 Wed
14/10 Sun
16/10 Tue
21/10 Sun
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14-18/10
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22-29/10
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