Presentation is loading. Please wait.

Presentation is loading. Please wait.

Profiling of human CD4+ T-cell subsets identifies the TH2-specific noncoding RNA GATA3-AS1  Huan Zhang, MD, PhD, Colm E. Nestor, PhD, Shuli Zhao, PhD,

Published byMillicent Patience Curtis Modified over 6 years ago

Similar presentations

Presentation on theme: "Profiling of human CD4+ T-cell subsets identifies the TH2-specific noncoding RNA GATA3-AS1  Huan Zhang, MD, PhD, Colm E. Nestor, PhD, Shuli Zhao, PhD,"— Presentation transcript:

1 Profiling of human CD4+ T-cell subsets identifies the TH2-specific noncoding RNA GATA3-AS1 
Huan Zhang, MD, PhD, Colm E. Nestor, PhD, Shuli Zhao, PhD, Antonio Lentini, MS, Barbara Bohle, PhD, Mikael Benson, MD, PhD, Hui Wang, PhD  Journal of Allergy and Clinical Immunology  Volume 132, Issue 4, Pages (October 2013) DOI: /j.jaci Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Analyses of human primary CD4+ T-cell subsets. A, Illustration of flow cytometric sorting. B, mRNA expression of IFNG, GATA3, RORC, and FOXP3. C, Principal component analysis of CD4+ T-cell subsets. D, Heat map presentation of subset-specific genes. High and low expression is shown in red and blue, respectively. TCM, CD4+ T central memory cells. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 GATA3-AS1 is a TH2-specific large intergenic noncoding RNA. A, GATA3-AS1 in human primary CD4+ T-cell subsets. B, GATA3-AS1 in polarized CD4+ T-cell subsets. C, GATA3-AS1 in human tissues and immune cells. D, GATA3-AS1 in human genome. E, Correlation between GATA3-AS1 and GATA3. F, GATA3-AS1 in in vitro cultured CD4+ T cells from allergic patients and control subjects. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig E1 Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Fig E2 Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Download ppt "Profiling of human CD4+ T-cell subsets identifies the TH2-specific noncoding RNA GATA3-AS1  Huan Zhang, MD, PhD, Colm E. Nestor, PhD, Shuli Zhao, PhD,"

Similar presentations

Control of immunopathology during chikungunya virus infection Caroline Petitdemange, PhD, Nadia Wauquier, PhD, Vincent Vieillard, PhD Journal of Allergy.

Control of immunopathology during chikungunya virus infection Caroline Petitdemange, PhD, Nadia Wauquier, PhD, Vincent Vieillard, PhD Journal of Allergy.
D-dimer: A biomarker for antihistamine-resistant chronic urticaria

D-dimer: A biomarker for antihistamine-resistant chronic urticaria
Peter Vadas, MD, PhD, Boris Perelman, PhD, Gary Liss, MD, MS 

Peter Vadas, MD, PhD, Boris Perelman, PhD, Gary Liss, MD, MS 
Critical link between glycogen synthase kinase 3β and forkhead box P3 in patients with chronic rhinosinusitis with nasal polyps  Xingmei Wu, MD, Sihua.

Critical link between glycogen synthase kinase 3β and forkhead box P3 in patients with chronic rhinosinusitis with nasal polyps  Xingmei Wu, MD, Sihua.
Human circulating group 2 innate lymphoid cells can express CD154 and promote IgE production  Laura Maggi, PhD, Gianni Montaini, BSc, Alessio Mazzoni,

Human circulating group 2 innate lymphoid cells can express CD154 and promote IgE production  Laura Maggi, PhD, Gianni Montaini, BSc, Alessio Mazzoni,
Reduced IFN-γ receptor expression and attenuated IFN-γ response by dendritic cells in patients with atopic dermatitis  Eva Gros, MSc, Susanne Petzold,

Reduced IFN-γ receptor expression and attenuated IFN-γ response by dendritic cells in patients with atopic dermatitis  Eva Gros, MSc, Susanne Petzold,
Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD 

Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD 
Ann-Marie M. Schoos, MD, PhD, Jacob D

Ann-Marie M. Schoos, MD, PhD, Jacob D
Atopic dermatitis: Age and race do matter!

Atopic dermatitis: Age and race do matter!
Distinct immunopathologic characteristics of various types of chronic rhinosinusitis in adult Chinese  Ping-Ping Cao, MD, Hua-Bin Li, MD, PhD, Bao-Feng.

Distinct immunopathologic characteristics of various types of chronic rhinosinusitis in adult Chinese  Ping-Ping Cao, MD, Hua-Bin Li, MD, PhD, Bao-Feng.
Identification of novel gene signatures in patients with atopic dermatitis complicated by eczema herpeticum  Lianghua Bin, MD, PhD, Michael G. Edwards,

Identification of novel gene signatures in patients with atopic dermatitis complicated by eczema herpeticum  Lianghua Bin, MD, PhD, Michael G. Edwards,
Is 9 more than 2 also in allergic airway inflammation?

Is 9 more than 2 also in allergic airway inflammation?
Desensitization to Chemotherapeutic Agents

Desensitization to Chemotherapeutic Agents
Advances in basic and clinical immunology in 2011

Advances in basic and clinical immunology in 2011
Recurrent anaphylaxis linked to pantoprazole

Recurrent anaphylaxis linked to pantoprazole
Rising prevalence of asthma is sex-specific in a US farming population

Rising prevalence of asthma is sex-specific in a US farming population
Lieuwe D. Bos, MSc, PhD, Peter J. Sterk, MD, PhD, Stephen J

Lieuwe D. Bos, MSc, PhD, Peter J. Sterk, MD, PhD, Stephen J
Jug r 2–reactive CD4+ T cells have a dominant immune role in walnut allergy  Luis Diego Archila, MSc, David Jeong, MD, Mariona Pascal, PhD, Joan Bartra,

Jug r 2–reactive CD4+ T cells have a dominant immune role in walnut allergy  Luis Diego Archila, MSc, David Jeong, MD, Mariona Pascal, PhD, Joan Bartra,
Yuichi Teraki, MD, Aika Sakurai, MD, Seiichi Izaki, MD 

Yuichi Teraki, MD, Aika Sakurai, MD, Seiichi Izaki, MD 
Allergy testing in predicting outcome of open food challenge to peanut

Allergy testing in predicting outcome of open food challenge to peanut

Similar presentations

Ads by Google