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Effects of Linaclotide in Patients With Irritable Bowel Syndrome With Constipation or Chronic Constipation: A Meta-analysis Elizabeth J. Videlock, Vivian Cheng, Filippo Cremonini Clinical Gastroenterology and Hepatology Volume 11, Issue 9, Pages e3 (September 2013) DOI: /j.cgh Copyright © 2013 AGA Institute Terms and Conditions
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Figure 1 Forest plot showing random-effects RR estimates with the corresponding 95% CI for being a responder on linaclotide vs placebo in IBS-C. (A) FDA responder; (B) abdominal pain responder; (C) CSBM responder; (D) adequate relief responder. Clinical Gastroenterology and Hepatology , e3DOI: ( /j.cgh ) Copyright © 2013 AGA Institute Terms and Conditions
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Figure 2 Forest plot showing random-effects RR estimates with the corresponding 95% CI for being a responder on linaclotide vs placebo in CC. (A) CSBM responder; (B) abdominal discomfort responder; (C) adequate relief responder. Clinical Gastroenterology and Hepatology , e3DOI: ( /j.cgh ) Copyright © 2013 AGA Institute Terms and Conditions
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Figure 3 Forest plot showing RR of developing diarrhea on low and higher dose linaclotide compared with placebo. Clinical Gastroenterology and Hepatology , e3DOI: ( /j.cgh ) Copyright © 2013 AGA Institute Terms and Conditions
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Supplementary Figure 1 Meta-analysis flow.
Clinical Gastroenterology and Hepatology , e3DOI: ( /j.cgh ) Copyright © 2013 AGA Institute Terms and Conditions
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Supplementary Figure 2 Forest plot showing comparative and pooled effect of the 290- to 300-μg dose of linaclotide in IBS-C. Clinical Gastroenterology and Hepatology , e3DOI: ( /j.cgh ) Copyright © 2013 AGA Institute Terms and Conditions
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