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Molecular Therapy - Nucleic Acids

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Presentation on theme: "Molecular Therapy - Nucleic Acids"— Presentation transcript:

1 Molecular Therapy - Nucleic Acids
Antisense Oligonucleotides Targeting Angiogenic Factors as Potential Cancer Therapeutics  Bao T. Le, Prithi Raguraman, Tamer R. Kosbar, Susan Fletcher, Steve D. Wilton, Rakesh N. Veedu  Molecular Therapy - Nucleic Acids  Volume 14, Pages (March 2019) DOI: /j.omtn Copyright © 2018 The Author(s) Terms and Conditions

2 Figure 1 Antisense Oligonucleotide Mechanisms to Alter Gene Expression
Different colors in pre-mRNA structure indicate introns and exons. Molecular Therapy - Nucleic Acids  , DOI: ( /j.omtn ) Copyright © 2018 The Author(s) Terms and Conditions

3 Figure 2 Examples of Prominent Chemically Modified Nucleotides
Molecular Therapy - Nucleic Acids  , DOI: ( /j.omtn ) Copyright © 2018 The Author(s) Terms and Conditions

4 Figure 3 Design of Gapmer and Mixmer AO Constructs
Green blocks: modified nucleotides; yellow blocks: normal nucleotides. Molecular Therapy - Nucleic Acids  , DOI: ( /j.omtn ) Copyright © 2018 The Author(s) Terms and Conditions

5 Figure 4 Discovery Timeline of Angiogenic Factors
Molecular Therapy - Nucleic Acids  , DOI: ( /j.omtn ) Copyright © 2018 The Author(s) Terms and Conditions


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