1. Paucigranulocytic asthma: Uncoupling of airway obstruction from inflammation 
Omar Tliba, PhD, DVM, Reynold A. Panettieri, MD 
Journal of Allergy and Clinical Immunology 
Volume 143, Issue 4, Pages (April 2019)
DOI: /j.jaci
Copyright © 2018 The Authors Terms and Conditions

2. Fig 1
Conceptual model of the pathobiology of PGA. A variety of triggers induce alterations in structural cell function (myofibroblasts and epithelial, smooth muscle, and mast cells) that engender AHR. Typically, patients with PGA manifest insensitivity to corticosteroid therapy. In a corticosteroid-insensitive manner structural cells also modulate airway inflammatory responses, such as chemokine and cytokine secretion and leukocyte trafficking. Ach, Acetylcholine; M2R, muscarinic receptor 2; M3R, muscarinic receptor 3.
Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci )
Copyright © 2018 The Authors Terms and Conditions