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Harry M. Salinas, MD, Saiqa I. Khan, MD, Michael C

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Presentation on theme: "Harry M. Salinas, MD, Saiqa I. Khan, MD, Michael C"— Presentation transcript:

1 Prevention of vein graft intimal hyperplasia with photochemical tissue passivation 
Harry M. Salinas, MD, Saiqa I. Khan, MD, Michael C. McCormack, MBA, Justin R. Fernandes, MD, Lisa Gfrerer, MD, Michael T. Watkins, MD, Robert W. Redmond, PhD, William G. Austen, MD  Journal of Vascular Surgery  Volume 65, Issue 1, Pages (January 2017) DOI: /j.jvs Copyright © 2015 Society for Vascular Surgery Terms and Conditions

2 Fig 1 Vein graft diameter before and after release of arterial clamps at the time of the initial procedure. PTP, Photochemical tissue passivation; RB, rose bengal. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2015 Society for Vascular Surgery Terms and Conditions

3 Fig 2 Photochemical tissue passivation (PTP)-treated vein (left) and untreated control vein (right) after clamp release. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2015 Society for Vascular Surgery Terms and Conditions

4 Fig 3 Comparison of a photochemical tissue passivation (PTP)-treated vein (left) and untreated control vein (right) fixed 1 hour after placement of vein graft, stained with Verhoeff-van Gieson stain. The untreated control vein is excessively dilated and shows interruption of endothelium and distortion of intima, media, and adventitia. The PTP-treated vein is not excessively distended and demonstrates normal architecture. Scale bar = 0.25 mm. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2015 Society for Vascular Surgery Terms and Conditions

5 Fig 4 Intimal thickness 4 weeks after placement of vein graft. PTP, Photochemical tissue passivation; RB, rose bengal. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2015 Society for Vascular Surgery Terms and Conditions

6 Fig 5 Representative histologic section of an untreated control vein (left column), rose bengal (RB, no light)-treated vein (middle column), and photochemical tissue passivation (PTP)-treated vein (right column) after 4 weeks. Note the substantially increased intimal thickness in the untreated control and RB (no light) veins compared with the PTP-treated vein. Scale bar = 0.25 mm. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2015 Society for Vascular Surgery Terms and Conditions

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