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Fig. 1. Experimental workflow of the dAST method and computationally estimated operational space. Experimental workflow of the dAST method and computationally.

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Presentation on theme: "Fig. 1. Experimental workflow of the dAST method and computationally estimated operational space. Experimental workflow of the dAST method and computationally."— Presentation transcript:

1 Fig. 1. Experimental workflow of the dAST method and computationally estimated operational space.
Experimental workflow of the dAST method and computationally estimated operational space. (A) The workflow for detecting antibiotic susceptibility by measuring the quantity of a specific NA sequence (AST marker). Urine samples are incubated without and with antibiotics (ABX) (steps 1 and 2), AST markers are quantified in control (−ABX) and treated (+ABX) samples (step 3), and the CT ratios are analyzed (step 4). (B) Theoretical model that predicts a CT ratio as a function of pathogen DNA doubling time and antibiotic exposure time. The operational space gained by using digital counting compared with qPCR is outlined in red. Nathan G. Schoepp et al., Sci Transl Med 2017;9:eaal3693 Published by AAAS

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