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Jeremiah R. Brown, PhD, Richard P. Cochran, MD, Todd A

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1 Long-Term Survival After Cardiac Surgery is Predicted by Estimated Glomerular Filtration Rate 
Jeremiah R. Brown, PhD, Richard P. Cochran, MD, Todd A. MacKenzie, PhD, Anthony P. Furnary, MD, Karyn S. Kunzelman, PhD, Cathy S. Ross, MS, Craig W. Langner, MS, MBA, David C. Charlesworth, MD, Bruce J. Leavitt, MD, Lawrence J. Dacey, MD, Robert E. Helm, MD, John H. Braxton, MD, Robert A. Clough, MD, Robert F. Dunton, MD, Gerald T. O'Connor, PhD, DSc  The Annals of Thoracic Surgery  Volume 86, Issue 1, Pages 4-11 (July 2008) DOI: /j.athoracsur Copyright © 2008 The Society of Thoracic Surgeons Terms and Conditions

2 Fig 1 Adjusted survival plot by categories of postoperative estimated glomerular filtration rate (eGFR). Adjusted Kaplan-Meier survival plot stratified by postoperative eGFR (in order, from top to bottom): 90 or greater, 60 to 89, 30 to 59, 15 to 29, less than 15 mL · min−1 · 1.73 m−2. Curves were adjusted for age, sex, prior coronary artery bypass graft surgery, body mass index, diabetes, chronic obstructive pulmonary disease, priority, ejection fraction, number of diseased vessels, baseline hematocrit, and baseline eGFR. Ordinate graphs the proportion survived. Abscissa graphs person-years of follow-up. The Annals of Thoracic Surgery  , 4-11DOI: ( /j.athoracsur ) Copyright © 2008 The Society of Thoracic Surgeons Terms and Conditions

3 Fig 2 Adjusted survival plot by categories of postoperative estimated glomerular filtration rate (eGFR) after 30 days. Adjusted Kaplan-Meier survival plot stratified by postoperative eGFR (in order, from top to bottom): 90 or greater, 60 to 89, 30 to 59, 15 to 29, less than 15 mL · min−1 · 1.73 m−2. Curves were adjusted for age, sex, prior coronary artery bypass graft surgery, body mass index, diabetes mellitus, chronic obstructive pulmonary disease, priority, ejection fraction, number of diseased vessels, baseline hematocrit, and baseline eGFR. Ordinate graphs the proportion survived. Abscissa graphs person-years of follow-up. The Annals of Thoracic Surgery  , 4-11DOI: ( /j.athoracsur ) Copyright © 2008 The Society of Thoracic Surgeons Terms and Conditions

4 Fig 3 Five-year mortality plot by categories of preoperative and postoperative estimated glomerular filtration rate (eGFR). Five-year mortality is plotted by preoperative eGFR and postoperative eGFR in predefined categories of renal function. Regardless of preoperative eGFR category, eGFR on average worsens and has an exponential increase in 5-year mortality. The Annals of Thoracic Surgery  , 4-11DOI: ( /j.athoracsur ) Copyright © 2008 The Society of Thoracic Surgeons Terms and Conditions


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