1. Brucellosis control programme in Turkey: Mass vaccination with strains S-19 and Rev-1 administered by conjunctival route
Dr. Ahmet Murat SAYTEKİN
Brucellosis Reference and Vaccine Production Laboratory

2. What is Brucellosis ?
Brucellosis has been described as a chronic, contagiouse, zoonotic and reticulohistiocytic disease of wild and domestic animals.
It cause abortion and/or infertility through necrotic inflammations created by Brucella organisms in genital organs such as uterus, testis and udder.
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3. Common ways of transmission of the disease
If we would like to evaluate spread of the disease, we can say generally four Brucella species that threaten both animal and human’s health.
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4. Brucellosis is a worldwide disease that cause economic losses.
Why do we have to control
the disease?
Brucellosis is a worldwide disease that cause economic losses.
Animal losses
via abortions
Milk and other
animal products losses via abortions
İnfertility and stud depreciation via inflammations
Cause human health problems
Loss of motivation among farmers due to failure
Cannot export
animals or animal products
Labour
Losses
Treatment
Costs
Cannot be priceless
for human health
As a Result; Brucellosis is not only a disease,
but also a SOCIAL PROBLEM!!
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5. What has been done in Turkey so far in order to control of the disease?
The first control programme was carried out between in 1974 and Years
Second programme was carried out between in 1984 and Years
A seroprevalance study was carried out in 2011 and according to datas;
Prevalance of brucellosis has indicated that 2.6 % (results of the cattle test positive) and 6.9% (result of cattle herds test positive) for brucellosis.
Prevalance of brucellosis has indicated that 4.7 % (results of sheep and goats test positive) and 30% (result of sheep flocks test positive) for brucellosis .
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6. Vaccination of new young
What has been done in Turkey so far in order to control of the disease?
Strategies
Herd / Flock Prevalance > 10 % Mass vaccination
Vaccination of new young
replacement
Herd / Flock Prevalance % - 5 %
and
test and slaughtered
of adults
Herd / Flock Prevalance < 1 % Test and slaughtered
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7. What has been done in Turkey so far in order to control of the disease?
The new control and eradication programme has been started since January
According to new programme;
1-Mass vaccination, should be performed with live Brucella vaccines by administreted conjunctival route
2-Conjunctival Brucella melitensis Rev-1 vaccines should include live bacteria between 0.5 – 2 x 109 CFU / Per Dose
3-Conjunctival Brucella abortus S-19 vaccines should include live bacteria between 5 – 10 x 109 CFU / Per Dose
4-First year, all animals should be vaccinated (Mass vaccination) .
-In the second year, unvaccinated animals from the previous year and new young replacements (3-6 months age) both should be vaccinated. And this strategy should be continued in the following years.
5-There was planned one booster vaccination after 12 months later from the first vaccination just for cattles.
6- The programme will continue 10 years for cattles, 6 years for sheep and goats. After these periods, it will be carried out serosurveys and according to the surveys’ results, the project will be evaluated.
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8. Current Situation
According to current data there are 15 million cattles, 33.5 million sheep and, 11 million goats in Turkey offically. (September 2017)
Now we are in stage of serosurvey for sheep and goats (Six years from 2012). After the serosurvey and according to its results, we will decide to our new strategy among the strategies (which were mentioned before).
Also, current project have been still carrying out for cattles and vaccination will continue the end of the 2022 (ten years from 2012).
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9. Years and Numbers of Livestock Outbreaks
Cattles
Sheep and Goats
2012
1696
222
2013
1319
512
2014
596 75
2015
315 73
2016
438 84
OIE Annual Animal Health Report Notification of Turkey; 2012, 2013 ,2014, 2015 and 2016.
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10. Years and numbers of human cases
2000
10742
2001
15510
2002
17765
2003
14572
2004
18264
2005
14644
2006
10810
2007
11804
2008
11809
2009
9818
2010
7703
2011
7177
2012
6759
2013
7225
2014
4403
2015
4173
2016
5148
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15. Thank you
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