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Vipul Pareek, MD, Mary Welch, MD, Elizabeth Ravera, RN, Richard L

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Presentation on theme: "Vipul Pareek, MD, Mary Welch, MD, Elizabeth Ravera, RN, Richard L"— Presentation transcript:

1 Marked Differences in CNS Activity among EGFR Inhibitors: Case Report and Mini- Review 
Vipul Pareek, MD, Mary Welch, MD, Elizabeth Ravera, RN, Richard L. Zampolin, MD, Lecia V. Sequist, MD, Balazs Halmos, MD  Journal of Thoracic Oncology  Volume 11, Issue 11, Pages e135-e139 (November 2016) DOI: /j.jtho Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

2 Figure 1 (A) Computed tomography scan of chest showing progression in right upper lobe and left upper lobe lesions while the patient was receiving afatinib. (B) Computed tomography scan done 3 weeks after patient started treatment with rociletinib showing significant response in lung lesions. Journal of Thoracic Oncology  , e135-e139DOI: ( /j.jtho ) Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

3 Figure 2 Safittal and axial three-dimensional T1W postcontract magnetic resonance imaging (MRI) images. (A) Initial MRI while patient was receiving afatinib demonstrating no enhancing lesions. (B) MRI 1 month after cessation of afatinib and initiation of rociletinib demonstrating interval development of diffuse miliary leptomeningeal metastatic disease. (C) MRI after the patient had received osimertinib for 6 weeks demonstrating market improvement of leptomeningeal disease with minimal residual disease within the posterior fossa. Journal of Thoracic Oncology  , e135-e139DOI: ( /j.jtho ) Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

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