1. FTIR measurements from cortical and trabecular bone of rat tibia on day 22 post disease induction.
FTIR measurements from cortical and trabecular bone of rat tibia on day 22 post disease induction. FTIR measurements revealed that arthritic rats had mineral and collagen loss in trabecular bone (A and B). Celastrol-treated groups demonstrated increased mineral content of cortical and trabecular bone (A and C), as well as carbonate cortical content (D). Tibiae were collected at the time of sacrifice. Data are expressed as median with minimum and maximum interval. H, healthy; A, arthritic; E, celastrol early-treated; L, celastrol late-treated. Healthy, n=28; arthritic, n=21; celastrol early-treated, n=14; and celastrol late-treated, n=14. FTIR, Fourier transform infrared spectroscopy.
Rita Cascão et al. RMD Open 2017;3:e000438
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