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Open-label therapy with alirocumab in patients with heterozygous familial hypercholesterolemia: Results from three years of treatment  Robert Dufour,

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Presentation on theme: "Open-label therapy with alirocumab in patients with heterozygous familial hypercholesterolemia: Results from three years of treatment  Robert Dufour,"— Presentation transcript:

1 Open-label therapy with alirocumab in patients with heterozygous familial hypercholesterolemia: Results from three years of treatment  Robert Dufour, Jean Bergeron, Daniel Gaudet, Robert Weiss, G. Kees Hovingh, Zhizhi Qing, Feng Yang, Matthew Andisik, Albert Torri, Robert Pordy, Daniel A. Gipe  International Journal of Cardiology  Volume 228, Pages (February 2017) DOI: /j.ijcard Copyright © 2016 Swiss Tropical and Public Health Institute Terms and Conditions

2 Fig. 1 Patient disposition.
AE, adverse event, HeFH, heterozygous familial hypercholesterolemia, OLT, open-label treatment, Q2W, every 2weeks, Q4W, every 4weeks. International Journal of Cardiology  , DOI: ( /j.ijcard ) Copyright © 2016 Swiss Tropical and Public Health Institute Terms and Conditions

3 Fig. 2 Absolute LDL-C levels over time and achievement of (A) risk-based LDL-C goals and (B) LDL-C percentage change from baseline. International Journal of Cardiology  , DOI: ( /j.ijcard ) Copyright © 2016 Swiss Tropical and Public Health Institute Terms and Conditions

4 Fig. 3 Levels of other lipids and lipoproteins over time: (A) apo B, (B) non-HDL-C, (C) Lp(a), (D) HDL-C, and (E) triglycerides. Values shown on the charts are rounded to one decimal place. International Journal of Cardiology  , DOI: ( /j.ijcard ) Copyright © 2016 Swiss Tropical and Public Health Institute Terms and Conditions


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