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A Developmental Switch in Microglial HDAC Function

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Presentation on theme: "A Developmental Switch in Microglial HDAC Function"— Presentation transcript:

1 A Developmental Switch in Microglial HDAC Function
Hansruedi Mathys, Jay Penney, Li-Huei Tsai  Immunity  Volume 48, Issue 3, Pages (March 2018) DOI: /j.immuni Copyright © 2018 Elsevier Inc. Terms and Conditions

2 Figure 1 HDACs 1 and 2 Are Essential for Microglia Development, but Their Loss in Adult Microglia Reduces Pathology in a Mouse Model of Alzheimer’s Disease Genetic deletion of Hdac1 and Hdac2 in microglia prior to birth strongly impairs microglial development, resulting in reduced cell numbers and altered morphology (left). In contrast, deletion of Hdac1 and Hdac2 in adult microglia has no effect on cell number or morphology during homeostasis (middle). Hdac1-2 deletion from adult microglia in Alzheimer’s disease model mice reduces amyloid plaque burden, increases amyloid co-localization with microglia, and rescues cognitive deficits (right). Immunity  , DOI: ( /j.immuni ) Copyright © 2018 Elsevier Inc. Terms and Conditions

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