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Forest plot displaying the effect estimates comparing azithromycin and placebo treatment in subgroups defined by above (>0.39 ng·mL−1) or below (<0.39 ng·mL−1) the median level of serum desmosine for the COLUMBUS trial population. Forest plot displaying the effect estimates comparing azithromycin and placebo treatment in subgroups defined by above (>0.39 ng·mL−1) or below (<0.39 ng·mL−1) the median level of serum desmosine for the COLUMBUS trial population. The effect estimate shown is incident rate ratio for frequency of exacerbations, severe exacerbations and moderate exacerbations, and hazard ratio for time to first exacerbation. James D. Chalmers et al. ERJ Open Res 2018;4: ©2018 by European Respiratory Society
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