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Dynamic Detection of Anti–Human Leukocyte Antigen (HLA) Antibodies but not HLA-DP Loci Mismatches Can Predict Acute Graft-versus-Host Disease and Overall.

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Presentation on theme: "Dynamic Detection of Anti–Human Leukocyte Antigen (HLA) Antibodies but not HLA-DP Loci Mismatches Can Predict Acute Graft-versus-Host Disease and Overall."— Presentation transcript:

1 Dynamic Detection of Anti–Human Leukocyte Antigen (HLA) Antibodies but not HLA-DP Loci Mismatches Can Predict Acute Graft-versus-Host Disease and Overall Survival in HLA 12/12–Matched Unrelated Donor Allogeneic Hematopoietic Stem Cell Transplantation for Hematological Malignancies  Zhijuan Pan, Xiaoni Yuan, Yang Li, Xiaojin Wu, Wenjuan Zhu, Xiaojin Bao, Qinqin Zhao, Jun He  Biology of Blood and Marrow Transplantation  Volume 22, Issue 1, Pages (January 2016) DOI: /j.bbmt Copyright © 2016 American Society for Blood and Marrow Transplantation Terms and Conditions

2 Figure 1 Anti-HLA positive antibodies and aGVHD. (A) The cumulative incidence of aGVHD and anti-HLA antibodies. (B) The cumulative incidence of aGVHD and MFI. Biology of Blood and Marrow Transplantation  , 86-95DOI: ( /j.bbmt ) Copyright © 2016 American Society for Blood and Marrow Transplantation Terms and Conditions

3 Figure 2 Preformed anti-HLA positive antibodies and survival. (A) Preformed anti-HLA antibodies on OS for all patients. (B) Preformed anti-HLA antibodies and OS for AML/MDS patients. (C) Preformed anti-HLA antibodies and DFS for all patients. (D) Preformed anti-HLA antibodies and DFS and AML/MDS patients. Biology of Blood and Marrow Transplantation  , 86-95DOI: ( /j.bbmt ) Copyright © 2016 American Society for Blood and Marrow Transplantation Terms and Conditions

4 Figure 3 Anti-HLA antibodies with HLA-DP loci mismatches and outcomes. (A) Anti-HLA antibody negative group, HLA-DP loci mismatch/match and OS. (B) Anti-HLA antibody negative group, HLA-DP loci mismatch/match and DFS. (C) Anti-HLA antibody positive group, HLA-DP loci mismatch/match and relapse. Biology of Blood and Marrow Transplantation  , 86-95DOI: ( /j.bbmt ) Copyright © 2016 American Society for Blood and Marrow Transplantation Terms and Conditions

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