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Pre-pregnancy exposure to diesel exhaust predisposes offspring to asthma through IL- 1β and IL-17A  Jerica Lenberg, BS, Qian Qian, PhD, Zehua Sun, PhD,

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Presentation on theme: "Pre-pregnancy exposure to diesel exhaust predisposes offspring to asthma through IL- 1β and IL-17A  Jerica Lenberg, BS, Qian Qian, PhD, Zehua Sun, PhD,"— Presentation transcript:

1 Pre-pregnancy exposure to diesel exhaust predisposes offspring to asthma through IL- 1β and IL-17A 
Jerica Lenberg, BS, Qian Qian, PhD, Zehua Sun, PhD, Rafeul Alam, MD, PhD, Magdalena M. Gorska, MD, PhD  Journal of Allergy and Clinical Immunology  Volume 141, Issue 3, Pages e3 (March 2018) DOI: /j.jaci Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Pre-pregnancy model. A-F, Analysis of pups. G and H, Analysis of mothers. A, Total lung resistance, 12 to 19 pups/group (group description in the main text); the table includes statistical analysis of the resistance data. B, Peribronchial inflammation, 8 to 15 pups/group. C, BAL cell counts, 11 to 17 pups/group. D, Cytokine proteins in lung homogenates, 9 to 12 pups/group. E, Cytokine transcripts in the lung, 8 to 15 pups/group; F, Cytokine proteins in the BAL fluid, 11 to 17 pups/group. G and H, Transcripts for cytokines (Fig 1, G) and components of the Ahr pathway (Fig 1, H) in maternal lungs (gestation day 10.5), 6 to 8 mothers/group; *P < .05; **P < .01; ***P < .001. NS, Not significant. Journal of Allergy and Clinical Immunology  , e3DOI: ( /j.jaci ) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Cytokine depletion. Pups of DEP-exposed females were injected with antibodies against IL-1β (A-D; 7-10 mice/group), IL-17A (E-H; 8-12 mice/group), or control IgGs before immunization and again before challenge with OVA. Pups were examined for total lung resistance to methacholine (Fig 2, A and E), peribronchial inflammation (Fig 2, B and F), BAL cell counts (Fig 2, C and G), and pulmonary cytokine transcripts (Fig 2, D and H). Anticytokine antibody versus IgG control: *P < .05; **P < .01; ***P < .001. Journal of Allergy and Clinical Immunology  , e3DOI: ( /j.jaci ) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig E1 Pre-pregnancy model. C57BL/6 females were exposed intranasally (i.n.) to DEPs or PBS on indicated premating days (PMD). Offspring were injected intraperitoneally (i.p.) with OVA in alum or PBS, and then intranasally (i.n.) with OVA or PBS on indicated postnatal days (PND). Pups were analyzed 3 days after the final intranasal exposure. Journal of Allergy and Clinical Immunology  , e3DOI: ( /j.jaci ) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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