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Paclitaxel-Loaded Expansile Nanoparticles Delay Local Recurrence in a Heterotopic Murine Non-Small Cell Lung Cancer Model  Rong Liu, MD, PhD, Onkar V.

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Presentation on theme: "Paclitaxel-Loaded Expansile Nanoparticles Delay Local Recurrence in a Heterotopic Murine Non-Small Cell Lung Cancer Model  Rong Liu, MD, PhD, Onkar V."— Presentation transcript:

1 Paclitaxel-Loaded Expansile Nanoparticles Delay Local Recurrence in a Heterotopic Murine Non-Small Cell Lung Cancer Model  Rong Liu, MD, PhD, Onkar V. Khullar, MD, Aaron P. Griset, PhD, Jacqueline E. Wade, BS, Kimberly Ann V. Zubris, BS, Mark W. Grinstaff, PhD, Yolonda L. Colson, MD, PhD  The Annals of Thoracic Surgery  Volume 91, Issue 4, Pages (April 2011) DOI: /j.athoracsur Copyright © 2011 The Society of Thoracic Surgeons Terms and Conditions

2 Fig 1 Lewis lung carcinoma (LLC) viability after coculture with 5% paclitaxel-loaded expansile nanoparticles (pax-eNP [dark blue line]), unloaded eNP (red line), or paclitaxel suspended in Cremophor EL/ethanol (pax-C/E) control (light blue line) result in significant dose-dependent cytotoxicity, whereas eNP alone are nontoxic. *p < 0.05 pax-eNP versus unloaded eNP. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2011 The Society of Thoracic Surgeons Terms and Conditions

3 Fig 2 Endocytosis of rhodamine–expansile nanoparticles (eNP) in Lewis lung carcinoma (LLC) cells. Using Z-stacks from confocal microscopy, rhodamine-eNP (green) are confirmed to be inside the AlexaFluor 647-conjugated concanavalin A (ConA) labeled cell membrane (red) and within the cytosol at 24 hours. Nuclei are stained with 4′,6-diamidino-2-phenylindole (DAPI [blue]). Scale bar = 20 μm. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2011 The Society of Thoracic Surgeons Terms and Conditions

4 Fig 3 Local administration of paclitaxel-loaded expansile nanoparticles (pax-eNP) delays local recurrence of Lewis lung carcinoma (LLC) after resection. (A) Experimental outline. (B) Kaplan-Meier curve of freedom from local recurrence after tumor resection: 5% pax-eNP (dark blue line); unloaded eNP (red line); paclitaxel suspended in Cremophor EL/ethanol intravenously (pax-C/E IV [light blue line]); and resection only (green line). *p < 0.05 pax-eNP versus all other groups. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2011 The Society of Thoracic Surgeons Terms and Conditions

5 Fig 4 Growth rate (loglinear regression) of recurrent tumor after surgical resection. *p < 0.05 versus all other groups. Saline is indicated by green symbols; unloaded expansile nanoparticles (eNP) are indicated by red symbols; paclitaxel suspended in Cremophor EL/ethanol intravenously (pax-C/E IV) is indicated by light blue symbols; and paclitaxel-loaded expansile nanoparticles (pax-eNP) are indicated by dark blue symbols. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2011 The Society of Thoracic Surgeons Terms and Conditions

6 Fig 5 Overall survival after primary tumor resection. Kaplan-Meier curves demonstrate prolonged survival in mice treated with paclitaxel-loaded expansile nanoparticles (pax-eNP [dark blue line]) compared with unloaded eNP [red line], paclitaxel suspended in Cremophor EL/ethanol intravenously (pax-C/E IV [light blue line]), and resection only (green line). *p < 0.05 versus all other groups. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2011 The Society of Thoracic Surgeons Terms and Conditions

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