1. earching the best evidence
Step: 2 S
earching the
best evidence

2. Categories of evidence
I: RCT
Ia: Evidence from meta-analysis of RCTS
Ib: Evidence from at least one RCT
II: Controlled trials
IIa: Evidence from at least one controlled study without randomization
IIb: Evidence from at least one controlled study with quasi-randomization
III. Evidence from descriptive studies
IV. Evidence from expert committee reports and/or clinical experience of respected authorities

3. Search strategy - Search term: keywords using PICO - Search Database
Evidence-based database: systematic review
& meta-analysis
Medical database: original randomized
controlled trial (RCT)
- Study design/search
Clinical trials
Observational studies: cohort, case-control,
cross-sectional

4. Four-part clinical question
Is the antiretroviral prophylaxis given to pregnant women with HIV infection effective in reducing viral load and HIV mother-to-child transmission?
Therapy
Guideline for searching
Search term:
antiretrovirals and HIV and pregnant women
Study design: RCT or systematic review
Search database

5. Evidence-based databases
Search database
Evidence-based databases
Medical database
Clinical evidence
CRD
EBM online
Cochrane Library
PubMed
Scientific information

10. PubMed

24. Thank you