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Persistence of CAR4 cells is reduced after sustained TCR engagement

Published byLorraine Glenn Modified over 5 years ago

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Presentation on theme: "Persistence of CAR4 cells is reduced after sustained TCR engagement"— Presentation transcript:

1 Fig. 6. Persistence of CAR4 cells is reduced after sustained TCR engagement.
Persistence of CAR4 cells is reduced after sustained TCR engagement. (A) Percentage of CAR4 cells in the bone marrow 80 days after infusion into leukemia-free (CAR antigen−) or leukemia-bearing (CAR antigen+) male (HY+) and female (HY−) recipients (n = 5, *P < 0.05). (B) Percentage of caspase 3/7+ CAR4 cells (CD45.2+) in the bone marrow at day 80 compared to endogenous CD4 T cells (CD45.1+) (**P < 0.01, ***P < 0.001). (C and D) PD-1 expression of CAR4 cells and endogenous CD4 T cells in the same recipient at day 80 after infusion into leukemia-free or leukemia-bearing male (HY+) and female (HY−) recipients (***P < 0.001, ****P < , one-way ANOVA performed for all comparisons). Yinmeng Yang et al., Sci Transl Med 2017;9:eaag1209 Published by AAAS

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