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An Argonaute Protein Directs Nuclear Xrn2 Function

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Presentation on theme: "An Argonaute Protein Directs Nuclear Xrn2 Function"— Presentation transcript:

1 An Argonaute Protein Directs Nuclear Xrn2 Function
Daniele Hasler, Gunter Meister  Molecular Cell  Volume 48, Issue 4, Pages (November 2012) DOI: /j.molcel Copyright © 2012 Elsevier Inc. Terms and Conditions

2 Figure 1 Twi12 Directs Xrn2 Exonuclease to the Nucleus and Stimulates Its Activity Upon loading with tRNA 3′ fragments (red), Twi12 forms a complex with Xrn2 and Tan1 (TXT). The exonucleolytic activity of Xrn2 and TXT import into the macronucleus depend on the association with Twi12. In the nucleus, Xrn2 (possibly as part of TXT) is involved in various RNA processing and degradation pathways. Molecular Cell  , DOI: ( /j.molcel ) Copyright © 2012 Elsevier Inc. Terms and Conditions

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