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Novel adipokines, high molecular weight adiponectin and resistin, are associated with outcomes following lower extremity revascularization with autogenous.

Published bySibyl McBride Modified over 5 years ago

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Presentation on theme: "Novel adipokines, high molecular weight adiponectin and resistin, are associated with outcomes following lower extremity revascularization with autogenous."— Presentation transcript:

1 Novel adipokines, high molecular weight adiponectin and resistin, are associated with outcomes following lower extremity revascularization with autogenous vein  Christopher D. Owens, MD, MSc, Ji Min Kim, MPH, Nathanael D. Hevelone, MPH, Allen Hamdan, MD, Joseph D. Raffetto, MD, Mark A. Creager, MD, Michael S. Conte, MD  Journal of Vascular Surgery  Volume 51, Issue 5, Pages (May 2010) DOI: /j.jvs Copyright © 2010 Society for Vascular Surgery Terms and Conditions

2 Fig 1 (a) High molecular weight adiponectin (HMWA) is negatively correlated with insulin resistance as assessed by homeostasis model of insulin resistance (HOMA-IR), while (b) resistin is positively associated with inflammation as assessed by high sensitivity C-reactive protein (hsCRP). All values represent natural logarithm transformations. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2010 Society for Vascular Surgery Terms and Conditions

3 Fig 2 Multivariable analysis of primary graft patency in patients (n = 225) undergoing lower extremity bypass surgery with autogenous vein. After controlling for diabetes mellitus (DM), high sensitivity C-reactive protein (hsCRP >5 mg/L), redo bypass, African-American race (AA), critical limb ischemia (CLI), and non-single segment great saphenous vein (non-ssgsv), only high molecular weight adiponectin (HMWA) and AA race were associated with graft patency. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2010 Society for Vascular Surgery Terms and Conditions

4 Fig 3 Multivariable analysis for amputation-free survival (AFS) in patients (n = 225) undergoing infrainguinal vascular reconstruction with autogenous vein. (A) Resistin and high-sensitivity CRP (hsCRP >5 mg/L) were independently associated with loss of AFS in this cohort after controlling for high molecular weight adiponectin (HMWA), estimated glomerular filtration rate (eGFR), age, diabetes mellitus (DM), and critical limb ischemia (CLI). (B) In the diabetic-restricted cohort (n = 117), only resistin was significant for AFS. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2010 Society for Vascular Surgery Terms and Conditions

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