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Emergence of Preexisting MET Y1230C Mutation as a Resistance Mechanism to Crizotinib in NSCLC with MET Exon 14 Skipping  Sai-Hong Ignatius Ou, MD, PhD,

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Presentation on theme: "Emergence of Preexisting MET Y1230C Mutation as a Resistance Mechanism to Crizotinib in NSCLC with MET Exon 14 Skipping  Sai-Hong Ignatius Ou, MD, PhD,"— Presentation transcript:

1 Emergence of Preexisting MET Y1230C Mutation as a Resistance Mechanism to Crizotinib in NSCLC with MET Exon 14 Skipping  Sai-Hong Ignatius Ou, MD, PhD, Lauren Young, MS, Alexa B. Schrock, PhD, Adrienne Johnson, BS, Samuel J. Klempner, MD, Viola W. Zhu, MD, PhD, Vincent A. Miller, MD, Siraj M. Ali, MD, PhD  Journal of Thoracic Oncology  Volume 12, Issue 1, Pages (January 2017) DOI: /j.jtho Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

2 Figure 1 Computed tomography scans of the patient before crizotinib treatment, confirmed response to crizotinib, and at progression during crizotinib treatment. Journal of Thoracic Oncology  , DOI: ( /j.jtho ) Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

3 Figure 2 Comprehensive genomic profiling profiling of a pre–crizotinib treatment tumor tissue sample showing MNNG HOS Transforming gene (MET) exon 14 skipping alteration (D1010H) and the presence of Y1230C mutation (red circle) at a very low frequency (upper panel). Circulating tumor DNA assay detecting the presence of the original MET exon 14 skipping alteration and the Y1230C resistance mutation, both at reportable levels (lower panel). Percentages indicate the mutant allele frequency for the given assay. Journal of Thoracic Oncology  , DOI: ( /j.jtho ) Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

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