Download presentation
Presentation is loading. Please wait.
Published byYulia Yuwono Modified over 6 years ago
1
Histone deacetylase inhibitors: A novel class of therapeutic agents in diabetic nephropathy
H.B. Lee, H. Noh, J.Y. Seo, M.R. Yu, H. Ha Kidney International Volume 72, Pages S61-S66 (August 2007) DOI: /sj.ki Copyright © 2007 International Society of Nephrology Terms and Conditions
2
Figure 1 Acetylation induced by histone acetyltransferase (HAT) and deacetylation induced by histone deacetylase (HDAC) at lysine residue. Kidney International , S61-S66DOI: ( /sj.ki ) Copyright © 2007 International Society of Nephrology Terms and Conditions
3
Figure 2 Effect of TSA on (a) α-smooth muscle actin (α-SMA), (b) E-cadherin, and (c) fibronectin mRNA expression in NRK-52E cells treated by H2O2. Data are presented as mean±s.e. of four experiments. *P<0.05 vs control (without H2O2 and TSA, †P<0.05 vs H2O2 without TSA. Kidney International , S61-S66DOI: ( /sj.ki ) Copyright © 2007 International Society of Nephrology Terms and Conditions
4
Figure 3 Effect of TSA on histone H3 acetylation in NRK-52E cells treated by H2O2. Data are presented as mean±s.e. of four experiments. *P<0.05 vs control (without H2O2 and TSA, †P<0.05 vs H2O2 without TSA. Kidney International , S61-S66DOI: ( /sj.ki ) Copyright © 2007 International Society of Nephrology Terms and Conditions
5
Figure 4 Effect of N-acetylcysteine on histone H3 acetylation in NRK-52E cells treated by TGF-β1. Data are presented as mean±s.e. of four experiments. Kidney International , S61-S66DOI: ( /sj.ki ) Copyright © 2007 International Society of Nephrology Terms and Conditions
Similar presentations
© 2025 SlidePlayer.com. Inc.
All rights reserved.