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H.B. Lee, H. Noh, J.Y. Seo, M.R. Yu, H. Ha  Kidney International 

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Presentation on theme: "H.B. Lee, H. Noh, J.Y. Seo, M.R. Yu, H. Ha  Kidney International "— Presentation transcript:

1 Histone deacetylase inhibitors: A novel class of therapeutic agents in diabetic nephropathy 
H.B. Lee, H. Noh, J.Y. Seo, M.R. Yu, H. Ha  Kidney International  Volume 72, Pages S61-S66 (August 2007) DOI: /sj.ki Copyright © 2007 International Society of Nephrology Terms and Conditions

2 Figure 1 Acetylation induced by histone acetyltransferase (HAT) and deacetylation induced by histone deacetylase (HDAC) at lysine residue. Kidney International  , S61-S66DOI: ( /sj.ki ) Copyright © 2007 International Society of Nephrology Terms and Conditions

3 Figure 2 Effect of TSA on (a) α-smooth muscle actin (α-SMA), (b) E-cadherin, and (c) fibronectin mRNA expression in NRK-52E cells treated by H2O2. Data are presented as mean±s.e. of four experiments. *P<0.05 vs control (without H2O2 and TSA, †P<0.05 vs H2O2 without TSA. Kidney International  , S61-S66DOI: ( /sj.ki ) Copyright © 2007 International Society of Nephrology Terms and Conditions

4 Figure 3 Effect of TSA on histone H3 acetylation in NRK-52E cells treated by H2O2. Data are presented as mean±s.e. of four experiments. *P<0.05 vs control (without H2O2 and TSA, †P<0.05 vs H2O2 without TSA. Kidney International  , S61-S66DOI: ( /sj.ki ) Copyright © 2007 International Society of Nephrology Terms and Conditions

5 Figure 4 Effect of N-acetylcysteine on histone H3 acetylation in NRK-52E cells treated by TGF-β1. Data are presented as mean±s.e. of four experiments. Kidney International  , S61-S66DOI: ( /sj.ki ) Copyright © 2007 International Society of Nephrology Terms and Conditions


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