Presentation is loading. Please wait.

Presentation is loading. Please wait.

Homologous recombination deficiency scores correlate with drug‐induced cell death in primary ovarian cancer cells Homologous recombination deficiency scores.

Published byNancy Park Modified over 5 years ago

Similar presentations

Presentation on theme: "Homologous recombination deficiency scores correlate with drug‐induced cell death in primary ovarian cancer cells Homologous recombination deficiency scores."— Presentation transcript:

1 Homologous recombination deficiency scores correlate with drug‐induced cell death in primary ovarian cancer cells Homologous recombination deficiency scores correlate with drug‐induced cell death in primary ovarian cancer cells AVisualization of homologous recombination deficiency (HRD) score determination by counting lost chromosome regions. Total copy number (TCN) and B‐allele frequency (BAF) plots derived from Asc15 whole‐genome sequencing data are shown. Black squares illustrate chromosome regions summarized as HRD score.BHRD scores of patient‐derived ovarian cancer cell lines used for DeathPro drug screening.CHeat map of correlation coefficients (R2) and estimated false discovery rates (FDR) determined from systematic association of drug responses (AUCd: cell death, AUCpi: growth arrest) with HRD scores. FDR was estimated by random sampling.D–HDrug‐induced cell death (AUCd) or growth arrest (AUCpi) of all nine primary OC cell lines divided into two groups with low (< 10) or high (≥ 10) HRD score. Cytotoxicity induced by carboplatin (D), paclitaxel (E), azacytidine (F) and decitabine (G) correlates with HRD score. Growth arrest induced by temsirolimus (H) is reduced in HR deficient cells. R² values of not significant correlations are shown in italics. Data information: *P < 0.05 in two‐sided Welch's t‐test. Julia Jabs et al. Mol Syst Biol 2017;13:955 © as stated in the article, figure or figure legend

Download ppt "Homologous recombination deficiency scores correlate with drug‐induced cell death in primary ovarian cancer cells Homologous recombination deficiency scores."

Similar presentations

Effects of inhibiting inflammatory cell recruitment on fracture healing Treatment with CCR2 antagonist, INCB3344, led to impaired fracture healing compared.

Effects of inhibiting inflammatory cell recruitment on fracture healing Treatment with CCR2 antagonist, INCB3344, led to impaired fracture healing compared.
Microtubule perturbations cause Ste5 patches to form less reliably, delay patch formation, and cause patches to persist for less time Microtubule perturbations.

Microtubule perturbations cause Ste5 patches to form less reliably, delay patch formation, and cause patches to persist for less time Microtubule perturbations.
Culture type shapes drug‐induced growth arrest in ovarian cancer patient cells Culture type shapes drug‐induced growth arrest in ovarian cancer patient.

Culture type shapes drug‐induced growth arrest in ovarian cancer patient cells Culture type shapes drug‐induced growth arrest in ovarian cancer patient.
Abundance of proteins matching selected subcellular locations and functions in CaCo‐2 cells. Abundance of proteins matching selected subcellular locations.

Abundance of proteins matching selected subcellular locations and functions in CaCo‐2 cells. Abundance of proteins matching selected subcellular locations.
Schematic diagram of the three circuits analysed in this work.

Schematic diagram of the three circuits analysed in this work.
CRISPR knockdown of the mrdAB operon increases cell width at high repression strengths CRISPR knockdown of the mrdAB operon increases cell width at high.

CRISPR knockdown of the mrdAB operon increases cell width at high repression strengths CRISPR knockdown of the mrdAB operon increases cell width at high.
(A) gToW growth phenotypes occur in the absence of leucine, and red squares indicate a significant growth‐rate defect as compared with the empty plasmid.

(A) gToW growth phenotypes occur in the absence of leucine, and red squares indicate a significant growth‐rate defect as compared with the empty plasmid.
Hnf4g importance in human colon cancer organoids and regulation of the Hnf4a locus Hnf4g importance in human colon cancer organoids and regulation of the.

Hnf4g importance in human colon cancer organoids and regulation of the Hnf4a locus Hnf4g importance in human colon cancer organoids and regulation of the.
Sensitivity of RNA‐seq.

Sensitivity of RNA‐seq.
Functional analysis of duplicate pair CIK1–VIK1 (A) Genetic interaction profile similarity. Functional analysis of duplicate pair CIK1–VIK1 (A) Genetic.

Functional analysis of duplicate pair CIK1–VIK1 (A) Genetic interaction profile similarity. Functional analysis of duplicate pair CIK1–VIK1 (A) Genetic.
Validation of the CCE associations by mass spectrometry.

Validation of the CCE associations by mass spectrometry.
The TBON model. The TBON model. (A) Representative confocal images of E14Tg2A cells stained for Tcf3 (green), Nanog (red), Oct4 (magenta), and total β‐catenin.

The TBON model. The TBON model. (A) Representative confocal images of E14Tg2A cells stained for Tcf3 (green), Nanog (red), Oct4 (magenta), and total β‐catenin.
Comparative analysis of RNA and protein profiles.

Comparative analysis of RNA and protein profiles.
Highly correlating interaction profiles can predict functional similarity Highly correlating interaction profiles can predict functional similarity AROC.

Highly correlating interaction profiles can predict functional similarity Highly correlating interaction profiles can predict functional similarity AROC.
Prediction of IGHV status based on Factor 1 in the CLL data and validation on outlier cases on independent assays Prediction of IGHV status based on Factor.

Prediction of IGHV status based on Factor 1 in the CLL data and validation on outlier cases on independent assays Prediction of IGHV status based on Factor.
Confirmation of pool data with isogenic culture

Confirmation of pool data with isogenic culture
Luminex phosphorylation measurements are reproducible and have broad dynamic range Individual difference in insulin‐induced phosphorylation of ERK measured.

Luminex phosphorylation measurements are reproducible and have broad dynamic range Individual difference in insulin‐induced phosphorylation of ERK measured.
Correlating protein to mRNA and proteins per mRNA ratios

Correlating protein to mRNA and proteins per mRNA ratios
Coupling immunophenotypes to Drop‐seq data

Coupling immunophenotypes to Drop‐seq data
Expression of FUT9 supports tumor development

Expression of FUT9 supports tumor development

Similar presentations

Ads by Google