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Novel Mutations Involving NF-κB and B-Cell Signaling Pathways in Primary Cutaneous Large B-Cell Lymphoma, Leg-Type and Comparison with Sézary Syndrome 

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Presentation on theme: "Novel Mutations Involving NF-κB and B-Cell Signaling Pathways in Primary Cutaneous Large B-Cell Lymphoma, Leg-Type and Comparison with Sézary Syndrome "— Presentation transcript:

1 Novel Mutations Involving NF-κB and B-Cell Signaling Pathways in Primary Cutaneous Large B-Cell Lymphoma, Leg-Type and Comparison with Sézary Syndrome  Esther J. Kim, Daniel J. Lewis, Madeleine Duvic  Journal of Investigative Dermatology  Volume 137, Issue 9, Pages (September 2017) DOI: /j.jid Copyright © 2017 The Authors Terms and Conditions

2 Figure 1 Pathogenetic and clinical features of PCLBCL-LT in different stages. PCLBCL-LT, primary cutaneous large B-cell lymphoma, leg-type. Journal of Investigative Dermatology  , DOI: ( /j.jid ) Copyright © 2017 The Authors Terms and Conditions

3 Figure 2 Overview of NF-κB activation and the genetic aberrancies in PCLBCL-LT versus Sézary syndrome. Affected molecules in PCLBCL-LT are indicated in red, affected molecules in Sézary syndrome are indicated in blue, and therapeutic targets are indicated in green. CARD11, caspase recruitment domain family member 11; CD79A, cluster of differentiation 79A; CD79B, cluster of differentiation 79B; MYD88, myeloid differentiation primary response gene; PCLBCL-LT, primary cutaneous large B-cell lymphoma, leg-type; TLR, toll-like receptor. Reprinted from Koens et al., 2014, with permission from Elsevier. Journal of Investigative Dermatology  , DOI: ( /j.jid ) Copyright © 2017 The Authors Terms and Conditions


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