1. Volume 132, Issue 5, Pages 1947-1954 (May 2007)
Reduction of Hepatosteatosis and Lipid Levels by an Adipose Differentiation-Related Protein Antisense Oligonucleotide 
Yumi Imai, Gladys M. Varela, Malaka B. Jackson, Mark J. Graham, Rosanne M. Crooke, Rexford S. Ahima 
Gastroenterology 
Volume 132, Issue 5, Pages (May 2007)
DOI: /j.gastro
Copyright © 2007 AGA Institute Terms and Conditions

2. Figure 1
Effects of ADRP ASO treatment vs control ASO and vehicle on (A) ADRP mRNA and (B and C) protein levels in Lepob/ob mice. Immunofluorescence of ADRP in livers in Lepob/ob mice treated with (D) vehicle, (E) control ASO, or (F) ADRP ASO. Effects of ADRP ASO vs control ASO vs vehicle on (G) ADRP mRNA and (H and I) protein levels in DIO mice. Immunofluorescence of ADRP on liver sections in DIO mice treated with (J) vehicle (K) control ASO, or (L) ADRP ASO. Data are mean ± SE, n = 5–6, *P < .001 vs vehicle; **P < vs vehicle. Scale bar = 50 μm.
Gastroenterology  , DOI: ( /j.gastro )
Copyright © 2007 AGA Institute Terms and Conditions

3. Figure 2
Lack of effect of ADRP ASO on (A and B) ADRP protein in white adipose tissue (WAT) and skeletal muscle, and (C) TIP47 protein in liver detected by Western blot, and mRNA expression of (D) S3-12 and (E and F) TNF-α mRNA expression in liver and WAT.
Gastroenterology  , DOI: ( /j.gastro )
Copyright © 2007 AGA Institute Terms and Conditions

4. Figure 3
Effects of ADRP ASO vs control ASO vs vehicle on hepatic (A) triglyceride and (B) cholesterol contents, (C) serum ALT levels, and (D and E) steatosis on hematoxylin-eosin stained liver sections in Lepob/ob mice. Effects of ADRP-ASO vs control ASO vs vehicle on hepatic (F) triglyceride and (G) cholesterol contents, and (H) serum ALT levels in DIO mice. Data are mean ± SE, n = 5–6, *P < .001 vs vehicle; **P < vs vehicle. Scale bar = 50 μm.
Gastroenterology  , DOI: ( /j.gastro )
Copyright © 2007 AGA Institute Terms and Conditions

5. Figure 4
Effects of ADRP ASO vs control on (A and B) hepatic gene expression, and (C and D) triglyceride levels after Poloxamer treatment. Data are mean ± SE, n = 5, *P < .01 vs control ASO; **P < .001 vs control ASO.
Gastroenterology  , DOI: ( /j.gastro )
Copyright © 2007 AGA Institute Terms and Conditions

6. Figure 5
HOMA index (A), and hyperinsulinemic clamp (B–E) in Lepob/ob mice treated with ADRP ASO or control ASO. HOMA index (F), glucose tolerance (G), and IP insulin sensitivity (H) in DIO treated with ADRP ASO or control ASO. Data are mean ± SE, n = 4–6, *P < .05 vs control; **P < .01 vs control ASO.
Gastroenterology  , DOI: ( /j.gastro )
Copyright © 2007 AGA Institute Terms and Conditions