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Judy Nee, Mohammed Zakari, Michael A

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1 Efficacy of Treatments for Opioid-Induced Constipation: Systematic Review and Meta- analysis 
Judy Nee, Mohammed Zakari, Michael A. Sugarman, Julia Whelan, William Hirsch, Shahnaz Sultan, Sarah Ballou, Johanna Iturrino, Anthony Lembo  Clinical Gastroenterology and Hepatology  Volume 16, Issue 10, Pages e2 (October 2018) DOI: /j.cgh Copyright © 2018 AGA Institute Terms and Conditions

2 Figure 1 PRISMA flow diagram of studies identified, excluded, and finally included for the meta-analysis. Clinical Gastroenterology and Hepatology  , e2DOI: ( /j.cgh ) Copyright © 2018 AGA Institute Terms and Conditions

3 Figure 2 Funnel plot for all studies included in the analysis. Negative log relative risk values represent studies with superior efficacy for the drug compared to placebo. Clinical Gastroenterology and Hepatology  , e2DOI: ( /j.cgh ) Copyright © 2018 AGA Institute Terms and Conditions

4 Figure 3 Forest plot demonstrating the efficacy of all drugs compared to placebo. The relative risk with 95% CI is displayed for the risk of failure to respond to treatment to drug (“Events”) compared to placebo. Values below one represent a favorable result for drug treatment. Clinical Gastroenterology and Hepatology  , e2DOI: ( /j.cgh ) Copyright © 2018 AGA Institute Terms and Conditions


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