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MEK1 and AKT2 Mutations in Japanese Lung Cancer

Published byAnn-Charlotte Hansson Modified over 5 years ago

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Presentation on theme: "MEK1 and AKT2 Mutations in Japanese Lung Cancer"— Presentation transcript:

1 MEK1 and AKT2 Mutations in Japanese Lung Cancer
Hidefumi Sasaki, MD, PhD, Yu Hikosaka, MD, Osamu Kawano, MD, Satoru Moriyama, MD, PhD, Motoki Yano, MD, PhD, Yoshitaka Fujii, MD, PhD  Journal of Thoracic Oncology  Volume 5, Issue 5, Pages (May 2010) DOI: /JTO.0b013e3181d35236 Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions

2 FIGURE 1 MEK1 gene mutation. One hundred seventy-one nucleotide change from G to T at exon 2, introduces a substitution of lysine (K) to asparagine (N) at amino acid position 57 (K57N) of the MEK1 protein. Journal of Thoracic Oncology 2010 5, DOI: ( /JTO.0b013e3181d35236) Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions

3 FIGURE 2 AKT2 mutation at kinase domain, R371H, at exon 11. Left: forward sequence from lung cancer samples. Right: reverse sequence. Journal of Thoracic Oncology 2010 5, DOI: ( /JTO.0b013e3181d35236) Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions

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