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A Single Nucleotide Polymorphism in SLC7A5 Is Associated with Gastrointestinal Toxicity after High-Dose Melphalan and Autologous Stem Cell Transplantation.

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Presentation on theme: "A Single Nucleotide Polymorphism in SLC7A5 Is Associated with Gastrointestinal Toxicity after High-Dose Melphalan and Autologous Stem Cell Transplantation."— Presentation transcript:

1 A Single Nucleotide Polymorphism in SLC7A5 Is Associated with Gastrointestinal Toxicity after High-Dose Melphalan and Autologous Stem Cell Transplantation for Multiple Myeloma  Jennifer L. Giglia, Marquitta J. White, Andrew J. Hart, Juan J. Toro, César O. Freytes, Cherish C. Holt, Ying Cai, Scott M. Williams, Stephen J. Brandt  Biology of Blood and Marrow Transplantation  Volume 20, Issue 7, Pages (July 2014) DOI: /j.bbmt Copyright © 2014 American Society for Blood and Marrow Transplantation Terms and Conditions

2 Figure 1 Graphical representation of significant haplotype associations for SLC7A5 markers. Black lines denote the haplotypes with a value of P < 0.01 for the Global Likelihood Ratio test performed using UNPHASED. This tested the null hypothesis that the haplotype including a given set of markers would not be associated with TPN use. Red lines denote haplotypes that remained significant after correction for multiple testing. All of the significantly associating haplotypes included SNP rs Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2014 American Society for Blood and Marrow Transplantation Terms and Conditions


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