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Integrated research framework, bounded by population and ecology of care axes running from highly selected to managed care populations (Y-axis) and from highly interventional to observational study design approaches (X-axis). Integrated research framework, bounded by population and ecology of care axes running from highly selected to managed care populations (Y-axis) and from highly interventional to observational study design approaches (X-axis). Adapted from [10] with permission from the publisher. David Price et al. Breathe 2015;11:26-38 ©2015 by European Respiratory Society
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