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Effects of Daprodustat, a Novel Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor on Anemia Management in Japanese Hemodialysis Subjects Akizawa et.

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Presentation on theme: "Effects of Daprodustat, a Novel Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor on Anemia Management in Japanese Hemodialysis Subjects Akizawa et."— Presentation transcript:

1 Effects of Daprodustat, a Novel Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor on Anemia Management in Japanese Hemodialysis Subjects Akizawa et al. Am J Nephrol 2017;45:   (DOI: / ) Table 1. Demographic and clinical characteristics (safety population)

2 Effects of Daprodustat, a Novel Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor on Anemia Management in Japanese Hemodialysis Subjects Akizawa et al. Am J Nephrol 2017;45:   (DOI: / ) Fig. 1. CONSORT flow chart.

3 Effects of Daprodustat, a Novel Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor on Anemia Management in Japanese Hemodialysis Subjects Akizawa et al. Am J Nephrol 2017;45:   (DOI: / ) Table 2. Baseline values and mean changes in hemoglobin (intent-to-treat population)

4 Effects of Daprodustat, a Novel Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor on Anemia Management in Japanese Hemodialysis Subjects Akizawa et al. Am J Nephrol 2017;45:   (DOI: / ) Fig. 2. Mean hemoglobin changes over time (intent-to-treat population; mean ± SD).

5 Effects of Daprodustat, a Novel Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor on Anemia Management in Japanese Hemodialysis Subjects Akizawa et al. Am J Nephrol 2017;45:   (DOI: / ) Table 3. Pharmacokinetic exposure parameters, peak EPO, and peak VEGF concentrations (intent-to-treat population)

6 Effects of Daprodustat, a Novel Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor on Anemia Management in Japanese Hemodialysis Subjects Akizawa et al. Am J Nephrol 2017;45:   (DOI: / ) Table 4. Baseline values and changes from baseline in ferritin, transferrin, TIBC, total iron, hepcidin, and transferrin saturation (intent-to-treat population)


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