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High Frequency of Loss of Heterozygosity on Chromosome Region 9p21–p22 but Lack of p16INK4a/p19ARF Mutations in Greek Patients with Basal Cell Carcinoma.

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Presentation on theme: "High Frequency of Loss of Heterozygosity on Chromosome Region 9p21–p22 but Lack of p16INK4a/p19ARF Mutations in Greek Patients with Basal Cell Carcinoma."— Presentation transcript:

1 High Frequency of Loss of Heterozygosity on Chromosome Region 9p21–p22 but Lack of p16INK4a/p19ARF Mutations in Greek Patients with Basal Cell Carcinoma of the Skin  Zacharenia Saridaki, George Sourvinos, Demetrios A. Spandidos  Journal of Investigative Dermatology  Volume 115, Issue 4, Pages (October 2000) DOI: /j x Copyright © 2000 The Society for Investigative Dermatology, Inc Terms and Conditions

2 Figure 1 Representative examples of LOH detected in BCC. N, normal DNA; T, tumor DNA. Arrows indicate the position of a deleted allele. The faint bands in the position of the deleted alleles are interpreted as contamination by the adjacent normal tissue. Journal of Investigative Dermatology  , DOI: ( /j x) Copyright © 2000 The Society for Investigative Dermatology, Inc Terms and Conditions

3 Figure 2 Location of the eight markers on chromosome arm 9p and pattern of LOH in 10 cases. (•, LOH; ○, heterozygosity; , noninformative or no data.) Journal of Investigative Dermatology  , DOI: ( /j x) Copyright © 2000 The Society for Investigative Dermatology, Inc Terms and Conditions

4 Figure 2 Location of the eight markers on chromosome arm 9p and pattern of LOH in 10 cases. (•, LOH; ○, heterozygosity; , noninformative or no data.) Journal of Investigative Dermatology  , DOI: ( /j x) Copyright © 2000 The Society for Investigative Dermatology, Inc Terms and Conditions

5 Figure 3 Location of the four markers on chromosome arms 17p and 17q and pattern of LOH in 10 cases. •, LOH; ○, heterozygosity; , noninformative or no data. Journal of Investigative Dermatology  , DOI: ( /j x) Copyright © 2000 The Society for Investigative Dermatology, Inc Terms and Conditions

6 Figure 3 Location of the four markers on chromosome arms 17p and 17q and pattern of LOH in 10 cases. •, LOH; ○, heterozygosity; , noninformative or no data. Journal of Investigative Dermatology  , DOI: ( /j x) Copyright © 2000 The Society for Investigative Dermatology, Inc Terms and Conditions

7 Figure 4 Comparison of sequencing (anti-sense strand) electrophorograms of two samples. Sample 75 is heterozygous for a G/A polymorphism (shown as a C/T in the anti-sense strand) whereas sample 80 lacks this polymorphism. Journal of Investigative Dermatology  , DOI: ( /j x) Copyright © 2000 The Society for Investigative Dermatology, Inc Terms and Conditions

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