1. Department of Emergency Medicine Yonsei University Health System
Antibiotics in the ED
Yoo Seok Park
Department of Emergency Medicine
Yonsei University Health System

2. Physician working in the ED
- are on the frontline in the war against infections

3. Selection of antibiotics
Action mechanism
Inhibition of cell wall synthesis
Inhibition of DNA synthesis
Inhibition of protein wall synthesis
Inhibition of RNA synthesis
Interference with folate metabolism
Production of free radical

4. Selection of antibiotics
Bactericidal vs. bacteriostatic
: macrolides, tetracyclines, clindamycin, trimethoprim-sulfamethoxazole, chloramphenicol
Ability to reach the site of infection
: in high enough concentration
Absorption of the drug --- best route
Metabolism and excretion

5. Brief characteristics of antibiotics

7. Brief characteristics of antibiotics

8. Dosage adjustment

9. Etiology of common infection

10. Antibiotics of choice
Bug - drug - host approach

11. Antibiotics of choice

12. Antibiotics of choice

13. Antibiotics of choice

14. Antibiotics of choice

15. Antibiotics of choice

16. Antibiotics of choice

17. Antibiotics of choice

18. Antibiotics of choice

19. Antibiotics of choice

20. Antibiotics of choice

21. Antibiotics of choice

22. Antibiotics of choice

23. Antibiotics of choice

24. Toxicity Crossover allergies Interaction with warfarin
Penicilline and cephalosporine
Penicilline and carbapenem
Interaction with warfarin
: macrolides, fluoroquinolones, cephalosporines, tetracyclines, high-dose IV penicillines

26. Thank you!