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Volume 15, Issue 1, Pages 1-8 (June 2008)

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1 Volume 15, Issue 1, Pages 1-8 (June 2008)
Influence of maternal nicotine exposure during gestation and lactation on lactate dehydrogenase isoenzyme profile and transcript levels in developing neonatal rat lung  K. Gamieldien, G.S. Maritz  Pathophysiology  Volume 15, Issue 1, Pages 1-8 (June 2008) DOI: /j.pathophys Copyright © 2007 Elsevier Ireland Ltd Terms and Conditions

2 Fig. 1 The influence of maternal nicotine exposure during gestation and lactation on the LDH-isozyme profile of the lung of the offspring. At postnatal days 1 and 7 there are no differences between the control and nicotine groups. The %Density/mg protein of control lung of all the isoenzymes at postnatal days 14, 21, and 49 were lower (P<0.01) than that of the lungs of the nicotine exposed rats. Pathophysiology  , 1-8DOI: ( /j.pathophys ) Copyright © 2007 Elsevier Ireland Ltd Terms and Conditions

3 Fig. 2 The influence of maternal nicotine exposure during gestation and lactation on the LDH-1/LDH-5 ratios of the lungs of the offspring. At postnatal days 1, 14, 21 and 49 the LDH-1/LDH-5 ratios of control lungs were higher (P<0.01) than for the lungs of the nicotine exposed rats. No difference was observed at postnatal day 7 (P>0.05). Pathophysiology  , 1-8DOI: ( /j.pathophys ) Copyright © 2007 Elsevier Ireland Ltd Terms and Conditions

4 Fig. 3 The influence of maternal nicotine exposure during gestation and lactation on LD-M and LD-H mRNA expression in the lungs of the offspring. (A): Postnatal days 1 and 7; control vs. nicotine: P>0.05. Postnatal days 14–49; control vs. nicotine: P<0.01. (B): Postnatal days 1–49; control vs. nicotine: P<0.01). Pathophysiology  , 1-8DOI: ( /j.pathophys ) Copyright © 2007 Elsevier Ireland Ltd Terms and Conditions


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