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Contributions of bronchoscopic microsampling in the supplemental diagnosis of small peripheral lung carcinoma  Masazumi Watanabe, MD, PhD, Akitoshi Ishizaka,

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Presentation on theme: "Contributions of bronchoscopic microsampling in the supplemental diagnosis of small peripheral lung carcinoma  Masazumi Watanabe, MD, PhD, Akitoshi Ishizaka,"— Presentation transcript:

1 Contributions of bronchoscopic microsampling in the supplemental diagnosis of small peripheral lung carcinoma  Masazumi Watanabe, MD, PhD, Akitoshi Ishizaka, MD, PhD, Eiji Ikeda, MD, PhD, Akira Ohashi, PhD, Koichi Kobayashi, MD, PhD  The Annals of Thoracic Surgery  Volume 76, Issue 5, Pages (November 2003) DOI: /S (03)

2 Fig 1 Illustration of the bronchoscopic microsampling probe.
The Annals of Thoracic Surgery  , DOI: ( /S (03) )

3 Fig 2 Bronchoscopic microsampling procedure under fluoroscopy. The arrow indicates the radiopaque marker. The Annals of Thoracic Surgery  , DOI: ( /S (03) )

4 Fig 3 Cytokeratin fragment 19 in epithelial lining fluid. Epithelial lining fluid weight–uncorrected values are correlated with weight–corrected values (p < 0.001). The Annals of Thoracic Surgery  , DOI: ( /S (03) )

5 Fig 4 (A) Cytokeratin fragment 19 values in epithelial lining fluid. (B) Carcinoembryonic antigen values. (C) Sialyl SSEA-1 values. The box-whisker plots show the 25th and 75th percentiles, the median (horizontal line within the box), and the 10th and 90th percentiles (whiskers). *p < 0.05, **p < 0.01 (cancerous tissue group versus other groups). The Annals of Thoracic Surgery  , DOI: ( /S (03) )

6 Fig 5 Receiver operating characteristic curves for cytokeratin fragment 19 (CYFRA), carcinoembryonic antigen (CEA), and sialyl SSEA-1 (SLX). The areas under the curve values were for cytokeratin fragment 19, for carcinoembryonic antigen, and for sialyl SSEA-1. Cytokeratin fragment 19 versus carcinoembryonic antigen, p = ; cytokeratin fragment 19 versus sialyl SSEA-1, p = ; carcinoembryonic antigen versus sialyl SSEA-1, p = Cytokeratin fragment 19 was the most reliable marker. (FPR = false-positive rate; TPR = true-positive rate.) The Annals of Thoracic Surgery  , DOI: ( /S (03) )

7 Fig 6 Microscopic immunohistochemical staining of cytokeratin fragment 19. The expression of cytokeratin fragment 19 was prominent in tumor tissue, weak in tissue near the tumor (A and B), and absent in normal lung tissue (C and D). Arrowheads show cancer cells and arrows show cells at marginal region. Bar in A and C, 100 μm; B and D, 50 μm. The Annals of Thoracic Surgery  , DOI: ( /S (03) )

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