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Prescribing patterns of evidence-based heart failure pharmacotherapy and outcomes in the ASIAN-HF registry: a cohort study Tiew-Hwa K Teng, PhD, Jasper Tromp, MD, Wan Ting Tay, MAppStat, Inder Anand, MD, Wouter Ouwerkerk, PhD, Vijay Chopra, MD, Gurpreet S Wander, DM, Jonathan JL Yap, MBBS, Michael R MacDonald, MBChB, Chang Fen Xu, MBBS, Yvonne MF Chia, MBBS, Wataru Shimizu, MD, A Mark Richards, MD, Adriaan Voors, MD, Carolyn SP Lam, MBBS The Lancet Global Health Volume 6, Issue 9, Pages e1008-e1018 (September 2018) DOI: /S X(18) Copyright © 2018 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND 4.0 license Terms and Conditions
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Figure 1 Regional variation in uptake
ACE=angiotensin-converting enzyme. ARB=angiotensin receptor blockers. MRA=mineralocorticoid receptor antagonists. The Lancet Global Health 2018 6, e1008-e1018DOI: ( /S X(18) ) Copyright © 2018 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND 4.0 license Terms and Conditions
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Figure 2 Mean doses achieved by region
(A) Angiotensin-converting enzyme inhibitors or angiotensin receptor blockers. (B) β blockers. (C) Mineralocorticoid receptor antagonists. Achieved doses were calculated as a percentage of the dose recommended by guidelines. The Lancet Global Health 2018 6, e1008-e1018DOI: ( /S X(18) ) Copyright © 2018 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND 4.0 license Terms and Conditions
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Figure 3 Association of doses achieved with 1-year composite outcome of all-cause deaths or hospitalisation for heart failure (A) Angiotensin-converting enzyme inhibitors or angiotensin receptor blockers. (B) β blockers. (C) Mineralocorticoid receptor antagonists. Achieved doses were calculated as a percentage of the dose recommended by guidelines. We used inverse probability weighting to adjust for indication bias. The Lancet Global Health 2018 6, e1008-e1018DOI: ( /S X(18) ) Copyright © 2018 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND 4.0 license Terms and Conditions
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